SIGNIFICANCE OF EVIDENCE ABOUT ASCORBIC ACID AND COMMON COLD
SIGNIFICANCE OF EVIDENCE ABOUT ASCORBIC ACID AND COMMON COLD
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DOI：
10.1073/pnas.68.11.2678
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发表时间：
1971-01-01
影响因子：
11.1
通讯作者：
PAULING, L
中科院分区：
文献类型：
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作者：
PAULING, L
只有四项独立的双盲研究报告了在试验期开始时，与安慰剂相比，每天定期摄入超过100毫克的抗坏血酸在降低以普通方式接触感冒病毒和没有感冒的受试者普通感冒的发病率和综合发病率方面的效果。对这四项研究的统计分析导致否定了零假设，即在感冒发病率的99.86%可信水平和综合发病率的99.9978%可信水平下，抗坏血酸没有比安慰剂更强的保护力。
Only four independent double-blind studies have been reported of the effect of ascorbic acid regularly ingested in daily amounts more than 100 mg, in comparison with a placebo, in decreasing the incidence and integrated morbidity of the common cold for subjects exposed to cold viruses in the ordinary way and without colds when the test period began. A statistical analysis of these four studies leads to rejection of the null hypothesis that ascorbic acid has no more protective power than the placebo at the 99.86% level of confidence for the incidence of colds and the 99.9978% level of confidence for the integrated morbidity.