Depression and obesity
Depression and obesity
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DOI：
10.1016/s0006-3223(03)00608-5
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发表时间：
2003-08-01
影响因子：
10.6
通讯作者：
Allison, KC
中科院分区：
文献类型：
--
作者：
Stunkard, AJ;Faith, MS;Allison, KC
抑郁症（10%）和超重（65%）的患病率表明它们有可能同时发生，但它们在功能上相关吗？本报告采用主持人/调解人的区分来处理这一问题。调节因子，如抑郁症的严重程度，肥胖的严重程度，性别，社会经济地位（SES），基因与环境的相互作用和童年经历，指定为谁和在什么条件下发生的代理的影响。中介者，如饮食和体育活动，戏弄，饮食失调和压力，确定他们为什么以及如何发挥这些作用。青少年重度抑郁症患者成年后的身体质量指数（BMI = kg/m2）高于未患抑郁症的患者。在女性中，肥胖与重度抑郁症有关，并且这种关系在高SES的人中增加，而在男性中，抑郁症与肥胖之间存在反比关系，并且与SES无关。抑郁症和肥胖症的遗传易感性可以通过环境影响来表达。不良的童年经历促进了抑郁症和肥胖症的发展，而且，据推测，它们同时发生。由于关于这两个因素之间关系的大多数知识来自于专门针对其他主题的研究，因此对这种关系的系统探索将有助于阐明因果机制以及预防和治疗的机会。(C)2003生物精神病学学会。
The prevalence of depression (10%) and overweight (65%) indicates that there is a probability that they will co-occur, but are they functionally related? This report used the moderator/mediator distinction to approach this question. Moderators, such as severity of depression, severity of obesity, gender, socioeconomic status (SES), gene-by-environment interactions and childhood experiences, specify for whom and under what conditions effects of agents occur. Mediators, such as eating and physical activity, teasing, disordered eating and stress, identify why and how they exert these effects. Major depression among adolescents predicted a greater body mass index (BMI = kg/m(2)) in adult life than for persons who had not been depressed. Among women, obesity is related to major depression, and this relationship increases among those of high SES, while among men, there is an inverse relationship between depression and obesity, and there is no relationship with SES. A genetic susceptibility to both depression and obesity may be expressed by environmental influences. Adverse childhood experiences promote the development of both depression and obesity, and, presumably, their co-occurrence. As most knowledge about the relationship between these two factors results from research devoted to other topics, a systematic exploration of this relationship would help to elucidate causal mechanisms and opportunities for prevention and treatment. (C) 2003 Society of Biological Psychiatry.