Decoupled effects of bone mass, microarchitecture and tissue property on the mechanical deterioration of osteoporotic bones
Decoupled effects of bone mass, microarchitecture and tissue property on the mechanical deterioration of osteoporotic bones
复制标题
骨量、微结构和组织特性对骨质疏松骨机械退化的解耦影响
DOI：
10.1016/j.compositesb.2019.107436
复制
发表时间：
2019-11-15
影响因子：
13.1
通讯作者：
Cai, Lin
中科院分区：
文献类型：
--
作者：
Liu, Pan;Liang, Xiaoxiao;Cai, Lin
基于复合力学理论，提出以“骨量-微结构-组织特性”代替“骨量-骨质量”的三支柱框架，定量表征与这三个方面相关的骨质疏松性松质骨的力学退化，并据此定量表征骨量的个体和综合影响。本文采用基于ct的有限元方法（FEM）模拟健康小鼠和卵巢切除所致骨质疏松小鼠的骨样本，研究了骨微结构和组织特性对松质骨力学性能的影响。通过对健康、轻度骨质疏松和重度骨质疏松骨骼的比较，可以清楚地看到健康骨骼具有更大的骨容密度和纵向优势的优化结构，能够更有效地抵抗通常沿其纵向方向的日常负荷，而骨质疏松症不仅显著降低了骨容密度，而且大大恶化了微建筑拓扑结构。导致有效杨氏模量的显著减小和纵向优势的破坏。此外，通过计算机建模，我们解耦了三个主要因素，以探讨它们对骨质疏松症骨骼机械退化的个别影响。研究发现，鞋底骨质流失会使松质骨的有效杨氏模量呈指数级降低，微结构在确定骨的纵向优势等各向异性特征方面起主导作用；组织特性的变化对松质骨的有效杨氏模量似乎有轻微的线性影响。
Based on the theory of composite mechanics, a three-pillar framework "bone mass-microarchitecture-tissue property" instead of "bone mass-bone quality", is proposed to quantitively characterize the mechanical deterioration of osteoporotic cancellous bones related to the three aspects, and accordingly the individual and integrative influences of bone mass, microarchitecture and tissue property on the mechanical properties of cancellous bones are investigated via the mu CT-based finite element method (FEM) simulations of bone samples from healthy and ovariectomy-induced osteoporosis mice. Comparisons among the healthy, mild osteoporotic and severe osteoporotic bones clearly show that the healthy bones have a larger bone volume density and an optimized architecture exhibiting longitudinal superiority able to more efficiently resist the daily loadings which are commonly along their longitudinal direction, while osteoporosis does not only significantly reduce the bone volume density but also greatly deteriorate the microarchitectural topology, resulting in a distinct reduction in the magnitude of effective Young's moduli and a breakdown of the longitudinal superiority as well. Furthermore, through modeling in silico we decoupled the three major factors to probe into their individual effects on the mechanical deterioration of osteoporotic bones. It was found that sole bone loss would exponentially decrease the effective Young's moduli of cancellous bones, microarchitecture plays a dominant role in defining the anisotropic characteristics of bones such as the longitudinal superiority; and change of tissue property seems having a slight and linear influence on the effective Young's moduli of cancellous bones.