Delayed HBsAg clearance in chronic hepatitis B viral infection
Delayed HBsAg clearance in chronic hepatitis B viral infection
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慢性乙型肝炎病毒感染中 HBsAg 清除延迟
DOI：
10.1002/hep.1840010605
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发表时间：
1981
期刊：
影响因子：
13.5
通讯作者：
M. Ashcavai
中科院分区：
文献类型：
--
作者：
K. Lindsay;A. Redeker;M. Ashcavai
7例患者中描述的HBsAg持续13至98个月后，急性病毒性肝炎B，然后变得不可检测。所有患者随后均出现抗-HBs。在HBs抗原血症期间，5例患者的肝活检显示持续性病毒性肝炎。在5例患者中，通过HBsAg滴度的降低可预测HBsAg的逆转，即将阴性，在4例患者中，通过血清丙氨酸转氨酶的持续正常化可预测HBsAg的逆转。虽然慢性B型肝炎病毒感染患者HBsAg清除延迟并不常见，但似乎是可预测的。
Seven patients are described in whom HBsAg persisted for 13 to 98 months after acute viral hepatitis B and then became nondetectable. All patients subsequently developed anti‐HBs. During the period of HBs‐antigenemia, liver biopsies in five patients showed persistent viral hepatitis. Retrospectively, impending negativity of HBsAg was predictable in five patients by a decrease in HBsAg titer, and in four patients by persistent normalization of serum alanine aminotransferase. Although delayed clearance of HBsAg in patients with chronic hepatitis B virus infection is uncommon, it appears to be predictable.