Differential human brain activity induced by two perceptually indistinguishable gentle cutaneous stimuli
Differential human brain activity induced by two perceptually indistinguishable gentle cutaneous stimuli
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由两种感知上无法区分的温和皮肤刺激引起的人脑活动差异
DOI：
10.1097/wnr.0b013e32836164d4
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发表时间：
2013
期刊：
影响因子：
1.7
通讯作者：
Ishiwata K
中科院分区：
文献类型：
--
作者：
Watanabe N;Ishii K;Hotta H;Oda K;Sakata M;Toyohara J;Ishiwata K
我们研究了两种类型的机械刺激，这是以前报道的知觉无法区分，但有不同的影响自主反射的大脑活动的差异。作为脑活动的指标，用2-[18 F]氟-2-脱氧-D-葡萄糖（18 F-FDG）通过PET评价葡萄糖代谢。12名健康的年轻男性参与了这项研究。以交叉、随机、双盲方式使用两种类型的皮肤刺激工具，带微锥的软弹性体圆盘（微锥圆盘）或平面（平面圆盘）。每种类型的皮肤刺激工具施加在脸颊上，并获得18个F-FDG-PET扫描。与平盘刺激相比，在微锥盘刺激期间观察到右前扣带回皮质中更大的18 F-FDG摄取。然而，18 F-FDG摄取在这两种不同的刺激应用程序中没有不同的初级和次级躯体感觉皮层或皮层。分别有一名和三名参与者注意到使用微锥盘和扁平盘的刺激，并且刺激工具之间的感知没有差异。结果表明，右前扣带皮层差异响应不同类型的皮肤刺激，是感知难以区分的。
We examined differences in brain activity in response to two types of mechanical stimulation, which have been reported previously as being perceptually indistinguishable but having different impacts on autonomic reflexes. As an indicator of brain activity, glucose metabolism was evaluated by PET with 2-[18 F] fluoro-2-deoxy-D-glucose (18 F-FDG). Twelve healthy, young adult men participated in the study. Two types of cutaneous stimulation tools, soft elastomer discs with microcones (microcone disc) or flat surfaces (flat disc), were used in a crossover, randomized double-blind manner. Each type of cutaneous stimulation tool was applied on the cheeks and 18 F-FDG-PET scans were obtained. Greater 18 F-FDG uptake was observed in the right anterior cingulate cortex during microcone disc stimulation compared with flat disc stimulation. However, 18 F-FDG uptake during application of these two different stimuli was not different in the primary and secondary somatosensory cortices or insula. Stimulation using microcone discs and flat discs was noted by one and three participants, respectively, and there was no difference in the presence of perception between the stimulation tools. The results indicate that the right anterior cingulate cortex differentially responds to different types of cutaneous stimulation that are perceptually indistinguishable.