Agladupols A-E, triterpenoids from Aglaia duperreana.
Agladupols A-E, triterpenoids from Aglaia duperreana.
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DOI：
10.1021/np0702842
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发表时间：
2007-08
影响因子：
5.1
通讯作者：
Bo-Jun Xie;Sheng-ping Yang;Hua-dong Chen;J. Yue
中科院分区：
文献类型：
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作者：
Bo-Jun Xie;Sheng-ping Yang;Hua-dong Chen;J. Yue
从苦楝科米仔兰（Aglaiaduperreana）的叶和茎中分离得到3个新的apotirucallane型三萜化合物，分别命名为agladupols A-C（1- 3）和2个新的tirucallane型三萜化合物，分别命名为agladupols D和E（4和5）。化合物1 ~ 5的结构经波谱数据确证。提出了一个基于（13）CNMR的阿朴替鲁卡拉烷型和替鲁卡拉烷型三萜侧链C-21构型归属的一般规则。据此，对已知化合物21-O-甲基川楝子戊醇（1a）的相对立体化学进行了完全归属。
Three new apotirucallane-type triterpenoids, agladupols A-C (1- 3), and two new tirucallane-type triterpenoids, agladupols D and E (4 and 5), along with four known compounds, were isolated from the leaves and stems of Aglaia duperreana (Meliaceae). The structures of compounds 1- 5 were elucidated by spectroscopic data. A (13)C NMR-based general rule for assignment of the C-21 configuration in the side chain of apotirucallane- and tirucallane-type triterpenoids was proposed. According to this, the relative stereochemistry of 21- O-methyltoosendanpentol (1a), a known compound with the relative configurations of the stereocenters in the side chain undetermined, was completely assigned.