Cochlear implant-evoked cortical activation in children with cochlear nerve deficiency.
Cochlear implant-evoked cortical activation in children with cochlear nerve deficiency.
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DOI：
10.1097/mao.0b013e31826426d2
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Buchman CA
中科院分区：
文献类型：
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作者：
He S;Grose J;Hang AX;Buchman CA
目的报告耳蜗植入诱发皮层听觉诱发电位（eCAEP）在耳蜗神经缺损（CND）患儿中的应用结果。病例对照系列。高等院校学术转介中心。7名患有CND的儿童在其受影响的耳朵中植入了人工耳蜗。4名无CND的儿童作为对照。通过激活单个耳蜗植入电极引起eCAEP。发作反应（P1-N1-P2复合体）。7名CND儿童中有3名在广泛的电极范围内表现出eCAEP反应，尽管使用他们的植入物具有有限的或没有开放式言语感知能力。其中两名儿童的eCAEP的特征是潜伏期、振幅和可识别反应的电极数量存在显著差异。其余4只患有CND和言语感知差的耳朵具有与eCAEP不一致的多相反应。非CND耳朵具有良好的言语感知能力表现出强大的反应，所有电极刺激。在所有情况下，缺失eCAEP反应表明开放式言语感知技能较差。然而，在一些有CND影像学证据的儿童中，eCAEP发作反应是可测量的，表明可能是耳蜗神经发育不全而不是发育不全。在某些情况下，一些患有CND和言语感知差的儿童具有稳健的eCAEP，使得这种特定的测量对于预测这些儿童人工耳蜗植入后的良好言语感知结果的效用有限。多相反应的起源仍有待确定，但在某些情况下可能是体感起源。
To report the results of cochlear implant-elicited cortical auditory evoked potentials (eCAEP) in children with cochlear nerve deficiency (CND). Case control series. Tertiary academic referral center. Seven children with CND that have a cochlear implant in their affected ear. Four children without CND served as controls. eCAEPs were elicited by activation of individual cochlear implant electrodes. Onset responses (P1-N1-P2 complex). Three of 7 CND children demonstrated eCAEP responses across a broad range of electrodes despite having limited or no open set speech perception abilities using their implants. Two of these children had eCAEPs that were characterized by substantial variability in latency, amplitude, and number of electrodes with identifiable responses. The remaining 4 ears with CND and poor speech perception had multiphasic responses that are inconsistent with eCAEPs. Non-CND ears with excellent speech perception abilities demonstrated robust responses on all electrodes stimulated. Abent eCAEP responses were indicative of poor open-set speech perception skills in all cases. However, eCAEP onset responses were measurable in some children with imaging evidence of CND, indicating probable cochlear nerve hypoplasia rather than aplasia. That some children with CND and poor speech perception had robust eCAEPs in some instances makes this particular measure of limited utility for predicting good speech perception outcomes following cochlear implantation in these children. The origin of multiphasic responses remains to be determined but may be of somatosensory origin in some instances.