Adipocytokines during pregnancy and postpartum in women with gestational diabetes and healthy controls
Adipocytokines during pregnancy and postpartum in women with gestational diabetes and healthy controls
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DOI：
10.3275/8968
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发表时间：
2013-12-01
影响因子：
5.4
通讯作者：
Kedikova, S.
中科院分区：
文献类型：
--
作者：
Boyadzhieva, M.;Atanasova, I.;Kedikova, S.
背景资料：本研究旨在探讨妊娠期糖尿病（GDM）孕妇血清脂肪细胞因子水平在妊娠期和产后的变化及其与妊娠期主要代谢指标的关系。材料与方法：236例孕妇（GDM组127例，对照组109例）和50例产后妇女（妊娠期GDM组30例，对照组20例）。采用ELISA和EIA试剂盒检测妊娠期和产后血清脂肪细胞因子水平。母体脂肪细胞因子水平与某些代谢参数相关。结果如下：妊娠期糖尿病妇女妊娠期（p < 0.001; 0.0001）和产后（p < 0.002; 0.0001）脂联素水平较低，瘦素水平较高。GDM组血清Apelin水平明显低于对照组（p < 0.009）。然而，我们没有发现Apelin（p < 0.317）和Apelin（p < 0.218）的显著性。瘦素与孕前及孕期体重指数、糖化血红蛋白、胰岛素抵抗指数呈正相关，脂联素与之呈负相关。以脂联素8.2 μ g/ml和瘦素28.7 ng/ml为分界点，排除GDM的敏感性为83.6%/81.2%，特异性为56.6%/64.2%（曲线下面积分别为0.702和0.827）。结论：妊娠期糖尿病患者血清脂联素和瘦素水平在妊娠期和产后均与对照组存在差异。在我们的GDM组中，爱帕琳降低，而内脂素和内脂素无差异。这种改变的机制以及脂肪细胞因子是否可以作为妊娠早期GDM的预测因子还需要进一步的研究。(C)2013年，Editrice Kurtis
Background: This study aims to explore the changes in maternal serum adipocytokines during pregnancy and post partum in normal and complicated with gestational diabetes (GDM) pregnancies and to investigate the relationship between serum adipocytokines and some of major metabolic parameters. Materials and methods: 236 pregnant women (127 with GDM and 109 control group) and 50 postpartum women (30 with GDM during pregnancy and 20 controls). Using ELISA and EIA kits, serum levels of adipocytokines were tested during pregnancy and post partum. Maternal adipocytokines levels were correlated with some metabolic parameters. Results: Women with GDM had lower values of adiponectin and higher values of leptin during pregnancy (p < 0.001; 0.0001) and post partum (p < 0.002; 0.0001). Serum apelin was significantly lower in GDM group (p < 0.009). However, we did not find significance for resistin (p < 0.317) and apelin (p < 0.218). Positive correlation for leptin and negative for adiponectin was found for pre-pregnancy and pregnancy body mass index, glycated hemoglobin and homeostasis model assessment of insulin resistance index. Using cut point of 8.2 mu g/ml for adiponectin and 28.7 ng/ml for leptin could exclude GDM with a sensitivity of 83.6%/81.2% and specificity of 56.6%/64.2% (area under the curve 0.702 and 0.827). Conclusion: There are constant differences in adiponectin and leptin levels between GDM and control group during pregnancy and post partum. Apelin was decreased in our GDM group and no differences were found for resistin and visfatin. Further studies are required to verify the mechanism of this alteration and whether the adipocytokines can be predictors for GDM at an early stage of pregnancy. (C) 2013, Editrice Kurtis