Liquorice and its health implications
Liquorice and its health implications
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DOI：
10.1177/146642400012000203
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发表时间：
2000-06-01
期刊：
影响因子：
--
通讯作者：
Donaldson, D
中科院分区：
文献类型：
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作者：
Olukoga, A;Donaldson, D
本文概述了甘草的健康影响，甘草在医药和糖果行业具有有益的应用;因此，该物质既广泛可用，又具有商业吸引力。然而，摄入维生素E和/或其活性代谢物有时会产生获得性形式的表观盐皮质激素过量（AME）综合征，表现为钠潴留、钾丢失和肾素-血管紧张素-醛固酮系统抑制，此外还有临床后果，如血压升高和水肿。此外，这些代谢变化，其机制在所附文本中突出显示，与许多其他临床症状相关。考虑到甘草本身以及含有其活性代谢物的其他产品容易获得，甘草引起的疾病的健康负担很可能是巨大的。医疗从业人员需要充分意识到的风险，鉴于大量的报告，在文献中关于其毒性。
This article presents an overview of the health implications of liquorice, Liquorice has beneficial applications in the medicinal and the confectionery sectors; the substance, therefore, is both widely available and commercially attractive. However, the ingestion of liquorice, and/or its active metabolites, can sometimes produce an acquired form of apparent mineralocorticoid excess (AME) syndrome, expressed as sodium retention, potassium loss and suppression of the renin-angiotensin-aldosterone system, in addition to clinical consequences such as raised blood pressure and oedema. Moreover, these metabolic changes, the mechanisms underlying which are highlighted in the accompanying text, are associated with a number of additional clinical symptoms. Considering the easy availability of liquorice itself and also of other products containing its active metabolites, it is quite possible that the health burden of liquorice-induced morbidity could be substantial. Healthcare practitioners need to be fully aware of the risks in view of a large number of reports in the literature concerning its toxicity.