Protein-facilitated transport of hydrophobic molecules across the yeast plasma membrane
Protein-facilitated transport of hydrophobic molecules across the yeast plasma membrane
复制标题
DOI：
10.1002/1873-3468.13469
复制
发表时间：
2019-07-01
期刊：
影响因子：
3.5
通讯作者：
Van Bogaert, Inge N. A.
中科院分区：
文献类型：
--
作者：
Claus, Silke;Jezierska, Sylwia;Van Bogaert, Inge N. A.
在酵母中，质膜形成屏障，保护细胞不受外界影响，但也聚集并保存有价值的化合物。虽然通常认为疏水分子通过简单的扩散超越了这个检查点，但现在很明显，蛋白质促进的运输机制允许酵母中甘油三酯、脂肪酸、烷烃和甾醇的选择性进出口。在生物质生产过程中，疏水碳源以严格监管的方式有效地进出细胞，有助于避免毒性。此外，各种分子，如酵母信息素、次生代谢物和外源物，被输出以确保细胞间的交流，或增加生存的机会。本文综述了目前关于疏水化合物如何与质膜上的蛋白质促进转运系统相互作用以及如何在酵母质膜上实现选择性输入和输出的知识。讨论了模式生物酿酒酵母和非常规酵母。
In yeasts, the plasma membrane forms the barrier that protects the cell from the outside world, but also gathers and keeps valuable compounds inside. Although it is often suggested that hydrophobic molecules surpass this checkpoint by simple diffusion, it now becomes evident that protein-facilitated transport mechanisms allow for selective import and export of triglycerides, fatty acids, alkanes, and sterols in yeasts. During biomass production, hydrophobic carbon sources enter and exit the cell efficiently in a strictly regulated manner that helps avoid toxicity. Furthermore, various molecules, such as yeast pheromones, secondary metabolites and xenobiotics, are exported to ensure cell-cell communication, or increase chances of survival. This review summarizes the current knowledge on how hydrophobic compounds interact with protein-facilitated transport systems on the plasma membrane and how selective import and export across the yeast plasma membrane is achieved. Both the model organism Saccharomyces cerevisiae, as well as unconventional yeasts are discussed.