In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI
In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI
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DOI：
10.1016/j.neuroimage.2004.03.031
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发表时间：
2004-07-01
期刊：
影响因子：
5.7
通讯作者：
Koretsky, AP
中科院分区：
文献类型：
--
作者：
Aoki, I;Wu, YJL;Koretsky, AP
在体可视化脑解剖结构能够深入了解正常生理和病理生理。在此证明，在全身性氯化锰给药后，利用磁共振成像（MRI）能够在啮齿动物大脑中检测到神经结构。氯化锰的施用导致脉络丛和脑室周围器官的T - 1快速增强，这种增强扩散到脑室的脑脊液间隙和脑室周围组织。1天后，整个大脑在磁共振成像上都有增强，垂体、嗅球、皮质、基底前脑、海马、基底神经节、下丘脑、杏仁核和小脑呈现高强度。所获得的对比度能够使神经结构的特定特征可视化。齿状回的箭头状结构以及海马的CA1 - CA3区域、皮质层、小脑以及嗅球都能很容易地被观察到。对嗅球层、额叶和躯体感觉皮质的皮质层以及小脑进行了初步定位。全身性氯化锰能够无损地通过磁共振成像可视化神经结构。（C）2004爱思唯尔公司。保留所有权利。
Visualizing brain anatomy in vivo could provide insight into normal and pathophysiology. Here it is demonstrated that neuroarchitecture can be detected in the rodent brain using MRI after systemic MnCl2. Administration of MnCl2 leads to rapid T-1 enhancement in the choroid plexus and circumventricular organs, which spreads to the CSF space in ventricles and periventricular tissue. After 1 day, there was MRI enhancement throughout the brain with high intensity in the pituitary, olfactory bulb, cortex, basal forebrain, hippocampus, basal ganglia, hypothalamus, amygdala, and cerebellum. Contrast obtained enabled visualization of specific features of neuroarchitecture. The arrowhead structure of the dentate gyrus as well as the CA1 - CA3 region of the hippocampus and layers in cortex, cerebellum, as well as the olfactory bulb could be readily observed. Preliminary assignments of olfactory bulb layers, cortical layers in frontal and somatosensory cortex, and cerebellum were made. Systemic MnCl2 leads to MRI visualization of neuroarchitecture nondestructively. (C) 2004 Elsevier Inc. All rights reserved.