Spatial IMA1 regulation restricts root iron acquisition on MAMP perception.
Spatial IMA1 regulation restricts root iron acquisition on MAMP perception.
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DOI：
10.1038/s41586-023-06891-y
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发表时间：
2024-01
期刊：
影响因子：
64.8
通讯作者：
Min Cao;M. Platre;Huei-Hsuan Tsai;Ling Zhang;Tatsuya Nobori;Laia Armengot;Yintong Chen;Wenrong He;Lukas Brent;Núria S Coll;J. Ecker;Niko Geldner;Wolfgang Busch
中科院分区：
文献类型：
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作者：
Min Cao;M. Platre;Huei-Hsuan Tsai;Ling Zhang;Tatsuya Nobori;Laia Armengot;Yintong Chen;Wenrong He;Lukas Brent;Núria S Coll;J. Ecker;Niko Geldner;Wolfgang Busch
在宿主-微生物相互作用过程中，铁是至关重要的。宿主在感染期间限制可利用的铁是一种重要的防御策略，称为营养免疫。然而，这对面向外部的吸收组织构成了一个难题，如肠道上皮或植物根表皮，这些组织产生有利于铁生物可利用性的环境。例如，植物根主要从土壤中获取铁，当缺铁时，通过根际酸化和铁络合剂分泌等机制增加铁的利用率。然而，铁生物利用率的提高也有利于威胁植物健康的细菌的生长。在这里，我们报告了微生物相关的分子模式，如鞭毛蛋白，通过局部降解系统缺铁信号肽Iron Man 1(IMA1)来抑制拟南芥根部铁的获取。当细菌进入根组织时也会引起这种反应，但当它们栖息在根的外表面时就不会引起这种反应。IMA1本身具有调节根和地上部免疫的作用，影响根的定植水平和对细菌性叶部病原菌的抗性。我们的发现揭示了营养免疫的一种适应性分子机制，它影响铁的生物利用和吸收，以及免疫反应。
Iron is critical during host–microorganism interactions, , –. Restriction of available iron by the host during infection is an important defence strategy, described as nutritional immunity. However, this poses a conundrum for externally facing, absorptive tissues such as the gut epithelium or the plant root epidermis that generate environments that favour iron bioavailability. For example, plant roots acquire iron mostly from the soil and, when iron deficient, increase iron availability through mechanisms that include rhizosphere acidification and secretion of iron chelators, , –. Yet, the elevated iron bioavailability would also be beneficial for the growth of bacteria that threaten plant health. Here we report that microorganism-associated molecular patterns such as flagellin lead to suppression of root iron acquisition through a localized degradation of the systemic iron-deficiency signalling peptide Iron Man 1 (IMA1) inArabidopsis thaliana. This response is also elicited when bacteria enter root tissues, but not when they dwell on the outer root surface. IMA1 itself has a role in modulating immunity in root and shoot, affecting the levels of root colonization and the resistance to a bacterial foliar pathogen. Our findings reveal an adaptive molecular mechanism of nutritional immunity that affects iron bioavailability and uptake, as well as immune responses.