Pulmonary Delivery of Therapeutic and Diagnostic Gases.
Pulmonary Delivery of Therapeutic and Diagnostic Gases.
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治疗和诊断气体的肺部输送。
DOI：
10.1089/jamp.2017.1431
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发表时间：
2018
影响因子：
3.4
通讯作者：
Katz,Ira
中科院分区：
文献类型：
--
作者：
Zapol,WarrenM;Charles,HCecil;Martin,AndrewR;Sá,RuiC;Yu,Binglan;Ichinose,Fumito;MacIntyre,Neil;Mammarappallil,Joseph;Moon,Richard;Chen,JohnZ;Geier,EricT;Darquenne,Chantal;Prisk,GKim;Katz,Ira
国际气雾剂医学会第21届大会首次包括关于治疗和诊断气体的肺部给药的会议。在国际SAM内举行这一会议的理由是，在许多情况下，气体药物的肺部给药与气雾剂药物给药针对相同的治疗领域，而且在许多科学和技术方面与气雾剂药物给药相似。本文是对最近召开的国际SAM大会的一份报告，提供了每一次发言的摘要。涉及的主题包括使用一氧化氮治疗肺动脉高压的概念、测试和发展；使用真实的成人鼻腔复制品来评估脉冲氧气输送装置的性能；概述几种诊断气体模式；以及使用吸入氧气作为质子磁共振成像(MRI)造影剂，以成像支气管收缩恢复期间特定通气量分布的时间变化。讨论了吸入气体在医学上的这些不同应用的共同主题，以及治疗和诊断气体发展的未来前景。
The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session onPulmonary Delivery of Therapeutic and Diagnostic Gases.The rationale for such a session within ISAM is that the pulmonary delivery of gaseous drugs in many cases targets the same therapeutic areas as aerosol drug delivery, and is in many scientific and technical aspects similar to aerosol drug delivery. This article serves as a report on the recent ISAM congress session providing a synopsis of each of the presentations. The topics covered are the conception, testing, and development of the use of nitric oxide to treat pulmonary hypertension; the use of realistic adult nasal replicas to evaluate the performance of pulsed oxygen delivery devices; an overview of several diagnostic gas modalities; and the use of inhaled oxygen as a proton magnetic resonance imaging (MRI) contrast agent for imaging temporal changes in the distribution of specific ventilation during recovery from bronchoconstriction. Themes common to these diverse applications of inhaled gases in medicine are discussed, along with future perspectives on development of therapeutic and diagnostic gases.