Toxicity of bloodmeals from ivermectin-treated cattle to Anopheles gambiae s.l.
Toxicity of bloodmeals from ivermectin-treated cattle to Anopheles gambiae s.l.
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DOI：
10.1179/000349809x12459740922138
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发表时间：
2009-09-01
影响因子：
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通讯作者：
Miller, J. R.
中科院分区：
文献类型：
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作者：
Fritz, M. L.;Siegert, P. Y.;Miller, J. R.
测试了两种用作牛驱虫剂的驱虫药伊维菌素和莫昔克丁对疟疾媒介冈比亚按蚊的致死和亚致死作用。和一个.阿拉伯的。在实验室中，将伊维菌素直接添加到牛血中会降低以牛血为食的蚊子的存活率和繁殖力。伊维菌素在血粉中的半数致死浓度（LC 50），对于实验室种群的An。gambiae s.l.，是19.8 ppb。在田间，将含有伊维菌素或莫昔克丁的市售制剂以推荐剂量的三倍注射到牛体内。大多数（90%）的人。冈比亚有限公司在给药后2周内饲喂伊维菌素处理牛的动物在血餐后未能存活超过10天。没有鸡蛋被安。冈比亚有限公司在治疗后10天内喂食伊维菌素治疗的牛。相比之下，以莫昔克汀给药牛为食的蚊子的存活率和产卵量与以未给药牛为食的蚊子无差异。这些结果表明，作为综合控制方案的一部分，可以使用伊维菌素治疗牛，以减少导致人类疟疾寄生虫传播的嗜动物病媒种群。
Two anthelmintic drugs used as cattle dewormers, ivermectin and moxidectin, were tested for their lethal and sublethal effects on the malarial vectors Anopheles gambiae s.s. and An. arabiensis. In the laboratory, direct addition of ivermectin to bovine blood reduced the survivorship and fecundity of mosquitoes fed on the blood. The median lethal concentration (LC50) of ivermectin in the bloodmeal, for the laboratory populations of An. gambiae s.l., was 19.8 ppb. In the field, commercially available formulations containing ivermectin or moxidectin were injected into cattle at three times the recommended dose. Most (90%) of the An. gambiae s.s. that fed on the ivermectin-treated cattle within 2 weeks of treatment failed to survive more than 10 days post-bloodmeal. No eggs were deposited by An. gambiae s.s. that fed on ivermectin-treated cattle within 10 days of treatment. In contrast, the survivorship and egg production of the mosquitoes that fed on the moxidectin-treated cattle were no different from those feeding on untreated cattle. These results indicate that treatment of cattle with ivermectin could be used, as part of an integrated control programme, to reduce the zoophilic vector populations that contribute to the transmission of the parasites responsible for human malaria.