Electrophoresis of sheared polyelectrolytes
Electrophoresis of sheared polyelectrolytes
复制标题
剪切聚电解质的电泳
DOI：
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
A. Ladd
中科院分区：
文献类型：
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作者：
A. Ladd
剪切流破坏了柔性聚合物的球形对称性，这对聚电解质的电泳有一些有趣的结果。除了引入电泳速度的链长依赖性之外，还存在分子垂直于压力和电势的同轴梯度方向迁移的可能性。这已被证明在微流体毛细管内产生快速和高度局部化的DNA浓度，具有许多潜在的应用于基因组DNA的芯片上制备和分析。在这篇献给Daan Frenkel教授的论文中，我将描述一个在同轴流场和电场下的长链电泳运动的计算。图形摘要
ABSTRACT A shear flow breaks the spherical symmetry of a flexible polymer, which has some interesting consequences for the electrophoresis of polyelectrolytes. In addition to introducing a chain-length dependence of the electrophoretic velocity, there is also the possibility of migration of the molecule perpendicular to the direction of coaxial gradients in pressure and electric potential. This has been shown to produce a rapid and highly localised concentration of DNA within a microfluidic capillary, with a number of potential applications to on-chip preparation and analysis of genomic DNA. In this paper, dedicated to Prof. Daan Frenkel, I will describe a calculation of the electrophoretic motion of a long polyelectrolyte under a coaxial flow and electric field. GRAPHICAL ABSTRACT
影响因子：
8.6
作者：
Chen, Yu;Abrams, Ezra S.;Sturm, James C.
通讯作者：
Sturm, James C.