Genetic classification of intestinal-type and diffuse-type gastric cancers based on chromosomal loss and microsatellite instability
Genetic classification of intestinal-type and diffuse-type gastric cancers based on chromosomal loss and microsatellite instability
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DOI：
10.1007/s00428-003-0840-0
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发表时间：
2003-10-01
期刊：
影响因子：
3.5
通讯作者：
Rhyu, MG
中科院分区：
文献类型：
--
作者：
Kim, KM;Kwon, MS;Rhyu, MG
胃肠道肿瘤的分期与杂合性丢失（洛）和微卫星不稳定性（MSI）的存在相关。本研究探讨了洛程度的分类和MSI的存在对常表现出病灶内异质性的弥漫型和弥漫型胃癌的遗传学分类的意义。使用染色体3p、4p、5q、8p、9p、13q、17p和18q上的一组40个微卫星标记筛选来自116例胃癌的总共390个肿瘤灶。1例MSI阳性胃癌伴LOH阳性灶，19例胃癌伴相似程度的病灶内洛异质性。116例胃癌根据代表性病灶中MSI（16例）和洛（100例）的程度进行分类。MSI阳性病例主要见于泌尿系型（94%）、晚发型（平均年龄68岁）、早期（75%）（P
The stage of gastrointestinal cancers has been correlated with the loss of heterozygosity (LOH) and the presence of microsatellite instability (MSI). This study delineated the category of the extent of LOH and the presence of MSI for the genetic classification of the intestinal-type and diffuse-type gastric cancers that frequently exhibited intralesional heterogeneity. A total of 390 tumor foci from 116 gastric cancers were screened using a panel of 40 microsatellite markers on chromosomes 3p, 4p, 5q, 8p, 9p, 13q, 17p, and 18q. One MSI-positive gastric cancer accompanying a LOH-positive focus and 19 gastric cancers with an intralesional LOH heterogeneity with a similar extent were identified. One hundred and sixteen gastric cancers were categorized based on the presence of MSI (16 cases) and the extent of LOH (100 cases) in a representative focus. A large fraction of MSI-positive cases was found in the intestinal-type (94%), late-onset (mean age 68 years), early-stage (75%) diseases (P