Voxelized computational model for convection-enhanced delivery in the rat ventral hippocampus: comparison with in vivo MR experimental studies.
Voxelized computational model for convection-enhanced delivery in the rat ventral hippocampus: comparison with in vivo MR experimental studies.
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DOI：
10.1007/s10439-012-0566-8
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发表时间：
2012-09
影响因子：
3.8
通讯作者：
Sarntinoranont, Malisa
中科院分区：
文献类型：
--
作者：
Kim, Jung Hwan;Astary, Garrett W.;Kantorovich, Svetlana;Mareci, Thomas H.;Carney, Paul R.;Sarntinoranont, Malisa
对流增强递送（CED）是一种很有前景的局部递送技术，可用于克服血脑屏障（BBB）和治疗中枢神经系统（CNS）疾病。对于 CED，治疗剂直接注入脑组织，药物通过细胞外空间（被认为是高度曲折的多孔介质）扩散。在这项研究中，使用磁共振 (MR) 扩散张量成像数据集开发的 3D 计算模型用于使用我们小组先前开发的体素化模型来预测大鼠腹侧海马中的 CED 传输。将预测的白蛋白示踪剂分布与腹侧海马体内 CED 高达 10 μL Gd-DTPA 白蛋白示踪剂输注的 MR 测量分布进行比较。 5 和 10 μL 输注后预测和测量的组织分布体积和分布模式具有可比性。发现示踪剂占据了底层的标志性结构，并在流体阻力较小的区域（例如齿状回的分子层）中发现了优先运输。此外，示踪剂的扩散受到高流体阻力层的限制，例如齿状回的颗粒细胞层和锥体细胞层。在输注即将结束时观察到示踪剂泄漏到邻近的脑脊液空间中。
Convection-enhanced delivery (CED) is a promising local delivery technique for overcoming the blood–brain barrier (BBB) and treating diseases of the central nervous system (CNS). For CED, therapeutics are infused directly into brain tissue and the drug agent is spread through the extracellular space, considered to be highly tortuous porous media. In this study, 3D computational models developed using magnetic resonance (MR) diffusion tensor imaging data sets were used to predict CED transport in the rat ventral hippocampus using a voxelized modeling previously developed by our group. Predicted albumin tracer distributions were compared with MR-measured distributions from in vivo CED in the ventral hippocampus up to 10 μL of Gd-DTPA albumin tracer infusion. Predicted and measured tissue distribution volumes and distribution patterns after 5 and 10 μL infusions were found to be comparable. Tracers were found to occupy the underlying landmark structures with preferential transport found in regions with less fluid resistance such as the molecular layer of the dentate gyrus. Also, tracer spread was bounded by high fluid resistance layers such as the granular cell layer and pyramidal cell layer of dentate gyrus. Leakage of tracers into adjacent CSF spaces was observed towards the end of infusions.
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DOI：
10.1016/j.nurt.2009.01.018
发表时间：
2009-04
期刊：
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
影响因子：
--
作者：
Bennewitz MF;Saltzman WM
通讯作者：
Saltzman WM
影响因子：
3
作者：
Astary, Garrett W.;Kantorovich, Svetlana;Carney, Paul R.;Mareci, Thomas H.;Sarntinoranont, Malisa
通讯作者：
Sarntinoranont, Malisa
影响因子：
3.2
作者：
Kim, Jung Hwan;Mareci, Thomas H.;Sarntinoranont, Malisa
通讯作者：
Sarntinoranont, Malisa
影响因子：
4.6
作者：
Linninger, Andreas A.;Somayaji, Mahadevabharath R.;Penn, Richard D.
通讯作者：
Penn, Richard D.
影响因子：
2
作者：
Linninger, Andreas A.;Somayaji, Mahadevabharath R.;Zhang, Libin
通讯作者：
Zhang, Libin