Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus
Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus
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DOI：
10.1021/ol006681k
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发表时间：
2000-12-14
期刊：
影响因子：
5.2
通讯作者：
Clardy, J
中科院分区：
文献类型：
--
作者：
Brady, SF;Singh, MP;Clardy, J
The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis end thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6,8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay.
