Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study.
Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study.
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DOI：
10.1111/j.1369-1600.2012.00449.x
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发表时间：
2013-07
影响因子：
3.4
通讯作者：
George MS
中科院分区：
文献类型：
--
作者：
Li X;Hartwell KJ;Borckardt J;Prisciandaro JJ;Saladin ME;Morgan PS;Johnson KA;Lematty T;Brady KT;George MS
许多研究小组现在正在使用血氧水平依赖（BOLD）功能性磁共振成像（fMRI）结果的分析，并将大脑区域活动的信息以"真实的时间"传递给扫描仪中的参与者。在这项研究中，我们探讨了尼古丁依赖的吸烟者在暴露于吸烟线索时，使用真实的时间fMRI（rtfMRI）神经反馈自我调节额叶皮层激活的可行性。10名吸烟者在3特斯拉的MRI扫描仪中显示与吸烟相关的视觉线索，以诱导他们对尼古丁的渴望。参与者被指示修改他们的渴望使用rtfMRI反馈与两种不同的方法。在“减少渴望”的范例中，参与者被指示“减少”他们的渴望，并减少前扣带皮层（ACC）的活动。在一个单独的“增加抵抗力”的范例中，参与者被要求增加他们对渴望的抵抗力，并增加中前额叶皮层（mPFC）的活动。我们发现，参与者能够显着减少“减少渴望”任务期间ACC中的BOLD信号（p = 0.028）。在"减少渴望"阶段，ACC激活减少与渴望等级降低之间存在显著相关性（p = 0.011）。相比之下，在"增加阻力"阶段，mPFC中的BOLD信号没有调制。这些初步结果表明，一些吸烟者可能能够通过rtfMRI使用神经反馈来自愿调节ACC激活，暂时减少吸烟线索诱导的渴望。需要进一步的研究来确定神经反馈rtfMRI的最佳参数，以及它是否最终可能成为尼古丁依赖的治疗工具。
Numerous research groups are now using analysis of blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI) results and relaying back information about regional activity in their brains to participants in the scanner in “real time”. In this study, we explored the feasibility of self-regulation of frontal cortical activation using real time fMRI (rtfMRI) neurofeedback in nicotine-dependent cigarette smokers during exposure to smoking cues. Ten cigarette smokers were shown smoking-related visual cues in a 3 Tesla MRI scanner to induce their nicotine craving. Participants were instructed to modify their craving using rtfMRI feedback with two different approaches. In a “reduce craving” paradigm, participants were instructed to “reduce” their craving, and decrease the anterior cingulate cortex (ACC) activity. In a separate “increase resistance” paradigm, participants were asked to increase their resistance to craving and to increase middle prefrontal cortex (mPFC) activity. We found that participants were able to significantly reduce the BOLD signal in the ACC during the “reduce craving” task (p=0.028). There was a significant correlation between decreased ACC activation and reduced craving ratings during the “reduce craving” session (p=0.011). In contrast, there was no modulation of the BOLD signal in mPFC during the “increase resistance” session. These preliminary results suggest that some smokers may be able to use neurofeedback via rtfMRI to voluntarily regulate ACC activation and temporarily reduce smoking cue-induced craving. Further research is needed to determine the optimal parameters of neurofeedback rtfMRI, and whether it might eventually become a therapeutic tool for nicotine dependence.
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影响因子：
--
作者：
Franklin, Teresa;Wang, Ze;Suh, Jesse J.;Hazan, Rebecca;Cruz, Jeffrey;Li, Yin;Goldman, Marina;Detre, John A.;O'Brien, Charles P.;Childress, Anna Rose
通讯作者：
Childress, Anna Rose
影响因子：
3.4
作者：
Hartwell KJ;Johnson KA;Li X;Myrick H;LeMatty T;George MS;Brady KT
通讯作者：
Brady KT
影响因子：
10.6
作者：
Caria, Andrea;Sitaram, Ranganatha;Birbaumer, Niels
通讯作者：
Birbaumer, Niels
DOI：
10.1073/pnas.0505210102
发表时间：
2005-12-20
影响因子：
11.1
作者：
deCharms, RC;Maeda, F;Mackey, SC
通讯作者：
Mackey, SC
DOI：
10.1073/pnas.1004745107
发表时间：
2010-07-27
影响因子：
11.1
作者：
Hong, L. Elliot;Hodgkinson, Colin A.;Stein, Elliot A.
通讯作者：
Stein, Elliot A.