Evidence of a Delayed Feedback Effect on the Mid-Day Plasma Cortisol Peak in Man
Evidence of a Delayed Feedback Effect on the Mid-Day Plasma Cortisol Peak in Man
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人类中午血浆皮质醇峰值延迟反馈效应的证据
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
G. Brandenberger
中科院分区：
文献类型：
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作者：
M. Follenius;G. Brandenberger
促肾上腺皮质激素（ACTH）释放受皮质类固醇反馈抑制的两个时间和动力学不同阶段的控制：快速速率敏感反馈和延迟或比例反馈（Jones，Hilhouse和Burden 1977）。尽管许多实验都涉及外源性皮质类固醇的反馈控制（Dallman和Yates 1969; Abe和Critchlow 1977），但对应激源产生的生理性皮质类固醇会改变随后的应激反应的证据仍然很少。最近的研究中，动物受到两个连续的刺激，支持的假设，即促进作用的压力平衡其反馈抑制作用（Dallman和琼斯1973年;江恩，Cryer和Pirkle 1977年;勒梅维尔，Abitbol，Beraud和Maniey 1979年）。
Adrenocorticotrophin (ACTH) release is under the control of two temporally and dynamically distinct phases of corticosteroid feedback inhibition: a fast rate-sensitive feedback and a delayed or proportional feedback (Jones, Hilhouse and Burden 1977). Whereas many experiments have dealt with feedback control by exogenous corticosteroids (Dallman and Yates 1969; Abe and Critchlow 1977), evidence that physiological corticosteroids secreted in response to a stressor will modify subsequent stress responses is still scant. Recent studies, in which animals were subjected to two sequential stimuli, support the hypotheses that a facilitatory effect of stressors balances their feedback-inhibitory effect (Dallman and Jones 1973; Gann, Cryer and Pirkle 1977; Le Mevel, Abitbol, Beraud and Maniey 1979).