Association of Systemic Inflammation Score With Atrial Fibrillation: A Case-Control Study With Propensity Score Matching
Association of Systemic Inflammation Score With Atrial Fibrillation: A Case-Control Study With Propensity Score Matching
复制标题
全身炎症评分与心房颤动的关联：倾向评分匹配的病例对照研究
DOI：
10.1016/j.hlc.2017.04.007
复制
发表时间：
2018-04-01
影响因子：
2.6
通讯作者：
Li, Yafei
中科院分区：
文献类型：
--
作者：
Zhang, Huan;Li, Jun;Li, Yafei
研究背景炎症在心房颤动（AF）的发生和发展中起着关键作用。我们开发了一种新的全身炎症评分（SIS）的基础上整合的生物标志物在临床环境中常规使用。我们的目的是探讨SIS和AF之间的关联。方法采用倾向评分匹配系统对376对AF病例和对照进行配对病例对照研究。SIS是通过整合白蛋白（ALB）、中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）和淋巴细胞与单核细胞比率（LMR）开发的。结果多因素条件Logistic回归分析显示，ALB和LMR水平升高与AF风险降低显著相关，OR值分别为0.74（95%CI：0.65，0.85）和0.73（95%CI：0.64，0.83）。与SIS = 1的患者相比，SIS = 3和4的患者的OR分别为2.16（95%CI：1.40 - 3.32）和2.55（95%CI：1.66 - 3.92）。结论本研究为全身炎症状态与房颤的发生相关提供了进一步的临床流行病学证据，SIS作为全身炎症状态的一个评价指标，可用于早期预测房颤的发生和了解房颤的发病机制。
Background Inflammation plays a key role in the initiation and progression of atrial fibrillation (AF). We developed a novel systemic inflammation score (SIS) based on integration of biomarkers used routinely in clinical settings. We aim to explore the association between SIS and AF.Methods A matched case-control study with 376 pairs of AF cases and controls was performed using a propensity score matching system. The SIS was developed by integrating albumin (ALB), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocytes to monocytes ratio (LMR). Univariate and multivariate analyses were performed to examine the association of each marker and SIS with AF.Results The conditional multivariate logistic regression analysis showed that elevated levels of ALB and LMR were significantly associated with decreased risk of AF with an OR of 0.74 (95% CI: 0.65, 0.85) and 0.73 (95% CI: 0.64, 0.83), respectively. Patients with elevated SIS had a significantly higher risk of AF. Compared to the patients with SIS equal to 1, the patients with SIS equal to 3 and 4 had an OR of 2.16 (95% CI: 1.40 3.32), and 2.55 (95% CI: 1.66, 3.92), respectively. The SIS was positively correlated with left atrial diameter and right atrial diameter in patients with AF.Conclusions In conclusion, this study provides further clinical epidemiological evidence that systemic inflammatory status was correlated with AF. The SIS, as an index to evaluate the intensity of systemic inflammatory status, could be useful for early prediction of AF development and understanding of AF mechanism.