Interferon modulates neuronal activity recorded from the hypothalamus, thalamus, hippocampus, amygdala and the somatosensory cortex
Interferon modulates neuronal activity recorded from the hypothalamus, thalamus, hippocampus, amygdala and the somatosensory cortex
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DOI：
10.1016/s0006-8993(96)00650-6
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发表时间：
1996-09-23
期刊：
影响因子：
2.9
通讯作者：
ReyesVazquez, C
中科院分区：
文献类型：
--
作者：
Dafny, N;PrietoGomez, B;ReyesVazquez, C
神经调节剂与经典定义的神经递质相互作用以调节各种生物过程。本研究的目的是研究干扰素-oc （IFN）是否可以被认为是一种神经调节剂。在三种不同的IFN给药途径之前和之后，对Sprague-Dawley大鼠的五个中枢神经系统结构的单细胞记录进行了记录，以证实IFN是一种神经调节剂。IFN调节了大部分下丘脑（70%）、杏仁核（76%）、海马体（75%）和皮质（82%）细胞，无论给药途径是在脑内还是外周给药（静脉注射或口服）。IFN三种给药途径对这四个中枢神经系统部位神经元活动的主要区别在于作用的开始时间。然而，丘脑神经元的反应不同。脑内注射干扰素可调节43%的丘脑神经元的活动，而静脉注射或静脉注射干扰素分别只调节25%和17%的神经元的活动。一般来说，IFN抑制下丘脑神经元活动，同时加速所有其他研究中枢神经系统部位的神经元活动。总之，IFN是一种内源性肽，可以外周和中枢合成和释放，无论是全身给药还是局部给药，对神经元活动的影响都是一样的。这表明IFN可以被认为是一种神经调节剂。
Neuromodulators interact with classically defined neurotransmitters to regulate a variety of biological processes. The aim of the present study was to study whether interferon-oc (IFN) can be considered as a neuromodulator. Single cell recordings from five CNS structures were recorded before and following three different routes of IFN administration in Sprague-Dawley rats to substantiate that IFN is a neuromodulator. IFN modulated the majority of the hypothalamic (70%), amygdala (76%), hippocampus (75%) and cortical (82%) cells whether the route of administration was within the brain or given peripherally (i.v. or i.p.). The main difference among the three routes of IFN administration on the neuronal activity of these four CNS sites was the onset of the effect. However, the thalamic neurons responded differently. IFN injection within the brain modulated activity of 43% of thalamic neurons, but only 25% and 17% of the neurons when IFN was given i.v. or i.p., respectively. IFN, in general, suppressed hypothalamic neuronal activity while accelerating neuronal activity in all the other studied CNS sites. in conclusion, IFN is an endogenous peptide synthesized and released both peripherally and centrally, with the same effects on neuronal activity whether it is given systemically or locally within the brain. This suggests that IFN can be considered as a neuromodulator.