Hemoglobin content in intramucosal gastric carcinoma as a marker of histologic differentiation: a clinical application of quantitative electronic endoscopy
Hemoglobin content in intramucosal gastric carcinoma as a marker of histologic differentiation: a clinical application of quantitative electronic endoscopy
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DOI：
10.1067/mge.2000.107707
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发表时间：
2000-08-01
影响因子：
7.7
通讯作者：
Oishi, T
中科院分区：
文献类型：
--
作者：
Yao, K;Yao, T;Oishi, T
背景资料：粘膜内胃癌的内镜颜色与癌组织内的粘膜血管有关。电子内窥镜的发展使得使用血红蛋白指数定量测量粘膜血红蛋白体积成为可能。本研究的目的是探讨该血红蛋白指数是否有助于评估早期胃癌的颜色变化，并验证该指数对区分组织学分化程度的诊断价值。癌性与非癌性血红蛋白指数的比值对26例分化型和18例未分化型粘膜内胃癌的癌粘膜进行了电子内镜影像学检查。分化型胃癌的癌性和非癌性粘膜的血红蛋白指数的平均比值高于未分化型胃癌（1.23：95%CI [1.15，1.31] vs.0.84：95%CI [0.81，0.88]）。结论：粘膜血红蛋白体积（血红蛋白指数）的测定可定量评价早期胃癌的内镜颜色，对鉴别未分化癌和分化癌有一定的参考价值。
Background: It has been suggested that the endoscopic color of intramucosal gastric carcinoma is correlated with mucosal vascularity within the carcinomatous tissue. The development of electronic endoscopy has made it possible to quantitatively measure the mucosal hemoglobin volume, using a hemoglobin index. The aims of the present study were to investigate whether this hemoglobin index is useful for evaluating the change in color of early gastric carcinoma and to verify the diagnostic value of this index for distinguishing between histologic degrees of differentiation.Methods: The ratios of the hemoglobin index of cancerous and non-cancerous mucosa for 26 differentiated and 18 undifferentiated intramucosal gastric carcinomas were determined from electronic endoscopic imaging data.Results: The mean ratio of the hemoglobin index of cancerous and non-cancerous mucosa in the differentiated gastric carcinomas was higher than it was in the undifferentiated carcinomas (1.23: 95% CI [1.15, 1.31] versus 0.84: 95% CI [0.81, 0.88]). The sensitivity and specificity for discriminating undifferentiated from differentiated carcinoma were 100% and 85%, respectively.Conclusion: Measurement of mucosal hemoglobin volume (hemoglobin index) is useful for evaluating the endoscopic color of early gastric carcinoma quantitatively and may be helpful in distinguishing differentiated from undifferentiated carcinoma.