GLYCOGENOLYTIC EFFECT OF VASOPRESSIN IN THE CANINE LIVER
GLYCOGENOLYTIC EFFECT OF VASOPRESSIN IN THE CANINE LIVER
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DOI：
10.1152/ajplegacy.1960.199.1.136
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发表时间：
1960-01-01
影响因子：
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通讯作者：
VANITALLIE, TB
中科院分区：
文献类型：
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作者：
BERGEN, SS;SULLIVAN, R;VANITALLIE, TB
在禁食、未麻醉的狗中研究了合成的加压素和催产素对葡萄糖通过肝脏的影响。在激素给药前后通过长期植入这些血管的导管从门静脉、肝静脉和主动脉采集血样。还测量了对商业Pitressin和Pitocin的反应。门静脉注射5-60 U加压素（或Pitressin）后，肝静脉葡萄糖立即明显增加，10分钟达高峰，30分钟内恢复到基线水平。在此期间，门静脉中的葡萄糖浓度未能增加，并且在某些情况下降低。给药10-40 U催产素（或Pitocin）未能引起肝静脉葡萄糖浓度的任何变化。
The effect of synthetic vasopressin and oxytocin upon glucose flux accross the liver was studied in fasted, unanesthetized dogs. Blood samples were obtained before and after hormone administration from portal and hepatic veins and aorta by means of catheters chronically implanted in these vessels. Responses to commercial Pitressin and Pitocin also were measured. Immediately following intraportal administation of 5-60 U of vasopressin (or Pitressin) an appreciable increment of glucose appeared in the hepatic vein, reaching a peak at 10 minutes and returning to base line levels within 30 minutes. During this time, glucose concentration in the portal vein failed to increase and in some instances decreased. Administration of 10-40 U of oxytocin (or Pitocin) failed to induce any change in hepatic vein glucose concentration.