Synthesis of 5-aryl-1,2,3,4-tetrahydrobenzo[a]phenanthridines
Synthesis of 5-aryl-1,2,3,4-tetrahydrobenzo[a]phenanthridines
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DOI：
10.1023/a:1012355506689
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发表时间：
2001-02-01
影响因子：
0.9
通讯作者：
Basalaeva, LI
中科院分区：
文献类型：
--
作者：
Kozlov, NG;Basalaeva, LI
以2-萘胺系列的亚甲胺与环己酮缩合为原料，制备了先前未知的四氢[a]菲的衍生物，该衍生物含有邻苯喹啉和环己烯核。证明了不需要预先制备席夫碱就可以合成这类化合物的可能性。研究了亚甲胺芳香环上取代基对目标产物收率的影响。对合成的化合物进行了红外光谱、紫外光谱、核磁共振光谱和质谱分析。
Previously unknown derivatives of tetrahydro[a]phenanthridine containing annelated benzoquinoline and cyclohexene nuclei were prepared by condensation of azomethines of the 2-naphthylamine series with cyclohexanone. The possibility of synthesis of such compounds without preliminarily preparing Schiff bases was demonstrated. The effect of substituents in the aromatic ring of the azomethine on the yield of the target products was elucidated. The IR, UV, H-1 NMR, and mass spectra of the synthesized compounds were discussed.