Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?
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DOI：
10.1007/s00213-011-2509-8
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发表时间：
2012-04
影响因子：
3.4
通讯作者：
Motoki Watabe;Takahiro A. Kato;A. Monji;Hideki Horikawa;S. Kanba
中科院分区：
文献类型：
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作者：
Motoki Watabe;Takahiro A. Kato;A. Monji;Hideki Horikawa;S. Kanba
米诺环素长期以来一直作为四环素类抗生素应用于各种传染病，最近又在中风和多发性硬化症等脑部疾病的治疗中发现了新的应用。此外，米诺环素也被认为是治疗精神疾病的有效药物。目的研究米诺环素对人类心理活动的影响，采用双盲随机试验，对米诺环素对人类社会决策的影响进行了实验研究。方法49名健康志愿者接受了4天的米诺环素或安慰剂治疗，在此之后，他们玩了(1)信任游戏和(2)独裁者游戏，在信任游戏中，他们决定如何在自己和匿名伙伴之间分配资源。事实上，米诺环素组的信任行为略有减少。然而，米诺环素组在信任游戏中的冒险程度和对他人可信度的单独评估中确实显示出强烈的正相关，而安慰剂组则没有显示出这种相关性。结论这些结果表明米诺环素导致了更理性的决策策略，可能是通过增加情绪调节。由于米诺环素是众所周知的小胶质细胞激活的抑制剂，我们的发现可能为治疗理性决策的一个组成部分受损的精神状态开辟了一条新的可选途径。
RationaleMinocycline has long been applied to various infectious diseases as a tetracycline antibiotic and recently has found new application in the treatment of brain diseases such as stroke and multiple sclerosis. In addition, minocycline has also been suggested as an effective drug for psychiatric diseases. These suggestions imply that minocycline may modulate our mental activities, while the underlying mechanism remains to be clarified.ObjectiveTo investigate how minocycline influences human mental activity, we experimentally examined how minocycline works on human social decision making in a double-blind randomized trial.MethodsForty-nine healthy volunteers were administered minocycline or placebo over four days, after which they played (1) a trust game, in which they decided how much to trust an anonymous partner, and (2) a dictator game, in which they decided how to divide resources between themselves and an anonymous partner.ResultsThe minocycline group did not display increased trusting behavior or more altruistic resource allocation. In fact, the minocycline group displayed a slight reduction in trusting behavior. However, the minocycline group did show a strong positive correlation between the degree of risk taking in the trust game and in a separate evaluation of others' trustworthiness, whereas the placebo group showed no such correlation.ConclusionsThese results suggest that minocycline led to more rational decision-making strategies, possibly by increasing emotion regulation. Since minocycline is a well-known inhibitor of microglial activation, our findings may open a new optional pathway for treating mental states in which a component of rational decision making is impaired.