The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit
The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit
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DOI：
10.1046/j.1365-2125.2003.01969.x
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发表时间：
2004-02-01
影响因子：
3.4
通讯作者：
Rapeport, WG
中科院分区：
文献类型：
--
作者：
Purkins, L;Love, ER;Rapeport, WG
目的探讨饮食对I期病房限制性环境中肝功能和血脂的影响。饮食包括平衡的正常热量饮食、高碳水化合物高热量饮食和高脂肪高热量饮食。每种饮食在8天内以随机顺序食用，两个时期之间的恢复期为14天。在每个饮食期间和恢复期间的时间间隔测量各种实验室参数的血液浓度。结果血液转氨酶活性和甘油三酯浓度显着增加，而受试者消耗高碳水化合物高热量饮食，但不是当喂食高脂肪高热量饮食时。结论转氨酶和甘油三酯的升高是由饮食中的碳水化合物含量引起的，而不是由饮食中的碳水化合物含量引起的。它的热值。导致氨基转移酶和甘油三酯升高的碳水化合物是蔗糖而不是淀粉。强调了在I期研究中控制饮食的重要性。
Aim To investigate the effect of diet upon liver function tests and serum lipids within the restricted environment of a Phase I unit.Methods An open randomized three-way crossover study was designed with subjects consuming three types of diet. The diets comprised, a balanced normal calorie diet, a high-carbohydrate high-calorie diet and a high-fat high-calorie diet. Each diet was consumed in a randomized sequence over 8 days with a recovery period of 14 days between periods. The blood concentrations of various laboratory parameters were measured at intervals throughout each dietary period and during the recovery periods.Results Blood transaminase activity and triglyceride concentrations increased significantly whilst subjects consumed a high-carbohydrate high-calorie diet but not when fed either a high-fat high-calorie diet or a balanced normal calorie diet.Conclusions The rises in transaminases and triglycerides were caused by the carbohydrate content of the diet rather than its calorific value. Sucrose rather than starch was the carbohydrate which caused the rise in transaminases and triglycerides. The importance of controlling diet in Phase I studies is stressed.