Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats

Dysregulation of BMP9/BMPR2/SMAD signalling pathway contributes to pulmonary fibrosis and pulmonary hypertension induced by bleomycin in rats
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BMP9/BMPR2/SMAD信号通路失调导致博莱霉素诱导的大鼠肺纤维化和肺动脉高压

DOI:
10.1111/bph.15285
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发表时间:
2020-11-09
影响因子:
7.3
通讯作者:
Wang, Jian
Wang, Jian
中科院分区:
医学2区
文献类型:
--
作者:
Jiang, Qian;Liu, Chunli;Wang, Jian

文献摘要

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Pulmonary hypertension related to pulmonary fibrosis is classed as WHO Group III, one of the most common groups which lacks effective treatment options. In this study, we aimed to uncover the underlying mechanisms, particularly the involvement of the BMP9/BMPR2/SMAD signalling pathway, in this subtype of pulmonary hypertension.