Simulating a lesion in a basis function model of spatial representations: comparison with hemineglect.
Simulating a lesion in a basis function model of spatial representations: comparison with hemineglect.
复制标题
在空间表示的基函数模型中模拟病变：与半忽略的比较。
DOI：
10.1037/0033-295x.108.3.653
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发表时间：
2001
影响因子：
5.4
通讯作者：
Sejnowski,TJ
中科院分区：
文献类型：
--
作者：
Pouget,A;Sejnowski,TJ
空间表征的基函数理论解释了顶叶皮层中的神经元如何执行从感觉坐标到运动坐标的非线性变换。作者提出的计算机模拟显示，单侧顶叶病变导致基函数图中的神经元梯度可以解释偏侧运动障碍患者的行为，包括（a）线取消和线平分实验中的忽视;（B）同时在多个参考系中的忽视;（c）相对忽视，有时称为以物体为中心的忽视的一种形式;以及（d）无视共济失调的忽视。在模型中出现了同侧忽略，因为病变产生了不平衡的显着性的刺激，这是调制的身体在空间中的方向。这些结果有力地支持了人类空间表征的基函数理论，并在单细胞水平上提供了一个计算模型。
The basis function theory of spatial representations explains how neurons in the parietal cortex can perform nonlinear transformations from sensory to motor coordinates. The authors present computer simulations showing that unilateral parietal lesions leading to a neuronal gradient in basis function maps can account for the behavior of patients with hemineglect, including (a) neglect in line cancellation and line bisection experiments;(b) neglect in multiple frames of reference simultaneously;(c) relative neglect, a form of what is sometime called object-centered neglect; and (d) neglect without optic ataxia. Contralateral neglect arises in the model because the lesion produces an imbalance in the salience of stimuli that is modulated by the orientation of the body in space. These results strongly support the basis function theory for spatial representations in humans and provide a computational model of hemineglect at the single-cell level.