Regulatory RNA-binding proteins in senescence
Regulatory RNA-binding proteins in senescence
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DOI：
10.1016/j.arr.2012.02.006
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发表时间：
2012-09
影响因子：
13.1
通讯作者：
Wengong Wang
中科院分区：
文献类型：
--
作者：
Wengong Wang
衰老相关基因的表达，控制着衰老的进展和维持，在多个水平上受到调节。除了控制细胞衰老的转录机制外，过去十年的研究表明，转录后基因调控，特别是通过mRNA周转和翻译的变化，严重影响衰老细胞中的蛋白质表达模式。在转录后调控因子中，rna结合蛋白（rbp）对衰老相关蛋白谱的建立尤其有影响。在这篇综述中，我讨论了rbp在细胞衰老中的作用和调控其功能的分子机制的现有知识。
The expression of senescence-associated genes, which governs the progression and the maintenance of senescence, is regulated at multiple levels. Apart from the transcriptional mechanisms that control cellular senescence, studies over the past decade have revealed that post-transcriptional gene regulation, especially through changes in mRNA turnover and translation, critically influences protein expression patterns in the senescent cell. Among the post-transcriptional regulatory factors, RNA-binding proteins (RBPs) are particularly influential in the establishment of senescence-associated protein profiles. In this review, I discuss the current knowledge of the role of RBPs in cellular senescence and the molecular mechanisms that regulate their function.