Association between Antidepressant Treatment during Pregnancy and Postpartum Self-Harm Ideation in Women with Psychiatric Disorders: A Cross-Sectional, Multinational Study.
Association between Antidepressant Treatment during Pregnancy and Postpartum Self-Harm Ideation in Women with Psychiatric Disorders: A Cross-Sectional, Multinational Study.
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DOI：
10.3390/ijerph18010046
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发表时间：
2020-12-23
影响因子：
--
通讯作者：
Lupattelli A
中科院分区：
文献类型：
--
作者：
Vallee J;Wong Y;Mannino E;Nordeng H;Lupattelli A
这项研究试图估计怀孕期间的抗抑郁药和产后自我伤害想法（SHI）之间是否存在预防性关联，因为迄今为止这方面的知识尚不清楚。使用多国药物使用在怀孕期间的研究，我们纳入了一个样本的母亲谁是在产后五周到一年的调查问卷完成时，并报告了既存或新发抑郁症和/或焦虑在怀孕期间（n = 187）。产后SHI的频率（“经常/有时”=频繁，“几乎从未”=零星，“从不”）通过爱丁堡产后抑郁量表（EPDS）第10项测量，该项目为“我想到伤害自己”。母亲们回顾性报告了她们在怀孕期间使用抗抑郁药的情况。总体而言，52.9%的女性在怀孕期间服用抗抑郁药。15.2%的未用药女性和22.0%的既往妊娠期接受抗抑郁药治疗的女性报告了产后频繁SHI;与妊娠三个月相比，单次妊娠治疗后的比例更高（36.3% vs 18.0%）。相对于从未/几乎从未发生过SHI，妊娠期抗抑郁治疗与产后频繁SHI报告无预防性关联（加权RR：1.90，95% CI：0.79，4.56）。在患有产前抑郁/焦虑的女性人群中，既往妊娠期抗抑郁药物治疗与产后一年频繁报告SHI之间没有预防性关联。这项分析只是为孕妇提供精神疾病治疗决策的第一步。
This study sought to estimate whether there is a preventative association between antidepressants during pregnancy and postpartum self-harm ideation (SHI), as this knowledge is to date unknown. Using the Multinational Medication Use in Pregnancy Study, we included a sample of mothers who were in the five weeks to one year postpartum period at the time of questionnaire completion, and reported preexisting or new onset depression and/or anxiety during pregnancy (n = 187). Frequency of postpartum SHI (‘often/sometimes’ = frequent, ‘hardly ever’ = sporadic, ‘never’) was measured via the Edinburgh Postnatal Depression Scale (EPDS) item 10, which reads “The thought of harming myself has occurred to me”. Mothers reported their antidepressant use in pregnancy retrospectively. Overall, 52.9% of women took an antidepressant during pregnancy. Frequent SHI postpartum was reported by 15.2% of non-medicated women and 22.0% of women on past antidepressant treatment in pregnancy; this proportion was higher following a single trimester treatment compared to three trimesters (36.3% versus 18.0%). There was no preventative association of antidepressant treatment in pregnancy on reporting frequent SHI postpartum (weighted RR: 1.90, 95% CI: 0.79, 4.56), relative to never/hardly ever SHI. In a population of women with antenatal depression/anxiety, there was no preventative association between past antidepressant treatment in pregnancy and reporting frequent SHI in the postpartum year. This analysis is only a first step in providing evidence to inform psychiatric disorder treatment decisions for pregnant women.
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影响因子：
10.5
作者：
Hawton, K;Zahl, D;Weatherall, R
通讯作者：
Weatherall, R
影响因子：
7.4
作者：
Freeman, Marlene P.;Claypoole, Lauren D.;Cohen, Lee S.
通讯作者：
Cohen, Lee S.
影响因子：
9.8
作者：
Cooper, William O.;Willy, Mary E.;Ray, Wayne A.
通讯作者：
Ray, Wayne A.
DOI：
10.1016/s0140-6736(17)32802-7
发表时间：
2018-04-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cipriani A;Furukawa TA;Salanti G;Chaimani A;Atkinson LZ;Ogawa Y;Leucht S;Ruhe HG;Turner EH;Higgins JPT;Egger M;Takeshima N;Hayasaka Y;Imai H;Shinohara K;Tajika A;Ioannidis JPA;Geddes JR
通讯作者：
Geddes JR
影响因子：
13.6
作者：
Ekman, A;Dickman, PW;Litton, JE
通讯作者：
Litton, JE