Roles of IgE and Histamine in Mast Cell Maturation.
Roles of IgE and Histamine in Mast Cell Maturation.
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DOI：
10.3390/cells10082170
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发表时间：
2021-08-23
期刊：
影响因子：
6
通讯作者：
Furuta K
中科院分区：
文献类型：
--
作者：
Tanaka S;Furuta K
肥大细胞在免疫球蛋白E（IgE）介导的抗原刺激后被激活，并释放多种介质，包括组胺以触发炎症反应。Fcε受体I（FcεRI）是IgE的高亲和力受体，其表面表达水平受IgE的正调控。IgE可以保护培养的小鼠肥大细胞免于由白细胞介素-3剥夺诱导的凋亡性细胞死亡，并且某种IgE可以在缺乏抗原的情况下激活未成熟的肥大细胞，导致促炎细胞因子的释放和组胺合成的短暂增加。肥大细胞中的组胺合成被认为是小鼠结缔组织型肥大细胞成熟所必需的，这提高了IgE间接调节局部肥大细胞成熟的可能性。尽管“单体IgE效应”的概念在多大程度上与调节人肥大细胞功能相关仍存在争议，但抗IgE抗体的治疗作用可能与血清IgE浓度降低有关。由于血清IgE浓度的急剧增加，经常观察到特应性皮炎和慢性荨麻疹患者，密切调查的作用，IgE肥大细胞的成熟，应有助于开发新的治疗方法，这些炎症性疾病。
Mast cells are activated upon immunoglobulin E (IgE)-mediated antigen stimulation, and release a wide variety of mediators, including histamine to trigger inflammatory responses. The surface expression levels of Fcε receptor I (FcεRI), a high affinity receptor of IgE, were found to be positively regulated by IgE. IgE could protect murine cultured mast cells from apoptotic cell death induced by the deprivation of interleukin-3 and a certain kind of IgE could activate immature mast cells in the absence of antigens, leading to the release of pro-inflammatory cytokines and a transient increase in histamine synthesis. Histamine synthesis in mast cells was found to be required for the maturation of murine connective tissue-type mast cells, raising the possibility that IgE indirectly modulates local mast cell maturation. Although it remains controversial to what extent this concept of “monomeric IgE effects” could have relevance in the modulation of human mast cell functions, the therapeutic effects of anti-IgE antibodies might be accounted for in terms of the decreased serum IgE concentrations. Because drastic increases in serum IgE concentrations are often observed in patients with atopic dermatitis and chronic urticaria, a close investigation of the roles of IgE in mast cell maturation should contribute to development of novel therapeutic approaches for these inflammatory diseases.
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DOI：
10.1084/jem.20021806
发表时间：
2003-06-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gonzalez-Espinosa C;Odom S;Olivera A;Hobson JP;Martinez ME;Oliveira-Dos-Santos A;Barra L;Spiegel S;Penninger JM;Rivera J
通讯作者：
Rivera J
DOI：
10.1164/ajrccm.155.6.9196082
发表时间：
1997-06-01
影响因子：
24.7
作者：
Fahy, JV;Fleming, HE;Boushey, HA
通讯作者：
Boushey, HA
影响因子：
3.7
作者：
Altrichter S;Peter HJ;Pisarevskaja D;Metz M;Martus P;Maurer M
通讯作者：
Maurer M
影响因子：
14.2
作者：
Deza, Gustavo;Bertolin-Colilla, Marta;Gimenez-Arnau, Ana M.
通讯作者：
Gimenez-Arnau, Ana M.
影响因子：
5.3
作者：
Bambouskova, Monika;Polakovicova, Iva;Draber, Petr
通讯作者：
Draber, Petr