Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes
Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes
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DOI：
10.1016/j.jconrel.2008.07.026
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发表时间：
2008-10-21
影响因子：
10.8
通讯作者：
Boland, Thomas
中科院分区：
文献类型：
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作者：
Zhang, Changhong;Zhao, Kejia;Boland, Thomas
以二异氰酸酯、聚己内酯二醇和双环[2，3]二辛烯扩链剂为原料，合成了一种新型的可降解弹性阴离子线型聚氨酯。通过将聚合物与含有2，2（甲基亚氨基）二乙醇扩链剂的聚氨酯进行比较，表征了聚合物的化学结构、机械性能、降解速率和溶胀比。由于掺入带负电荷的羧基侧基，二羟乙基甘氨酸扩展的聚合物表现出更高的微相分离，在干燥条件下更好的机械性能，以及比对照更好的对环境刺激的敏感性，如通过其在升高的pH、较低的离子强度或较高的温度下的高溶胀比所证明的。膜的溶胀比在37 ° C下显示出作为pH的函数的可逆变化，膜在pH高于8.3时变得完全水溶性。以氯化耐尔蓝和溶菌酶为研究对象，研究了它们在该聚合物中的释放。两种化合物的释放速率受pH和离子强度的显著影响。溶胀比也受到溶菌酶负载在低pH值的影响。pH值依赖的属性被用来制造支架按需打印。Bicine扩展的聚氨酯可能对可能的药物递送应用、可定制的支架制造和其他潜在的生物医学应用感兴趣。(C)2008 Elsevier B.V.保留所有权利。
A novel degradable, elastic, anionic, and linear polyurethane was synthesized from hexamethylene diisocyanate, polycaprolactone diol, and a bicine chain extender. The chemical structure, mechanical properties, degradation rate, and swelling ratio were characterized by comparing the polymer with a polyurethane containing a 2,2(methylimino) diethanol chain extender. Due to the incorporation of negatively charged carboxyl side groups, the bicine extended polymers exhibited higher micro-phase separation, better mechanical properties in dry condition, and better sensitivity to environmental stimuli than controls, as demonstrated by its high swelling ratio at elevated pH, lower ionic strength, or higher temperature. The swelling ratio of membranes showed reversible change as the function of pH at 37 degrees C, the membranes becoming fully water soluble at pH above 8.3. Nile blue chloride and lysozyme were selected to study their release from this polymer. The release rates of both compounds were significantly influenced by the pH and ionic strength. The swelling ratios were also influenced by lysozyme loading at low pH. The pH dependent properties were used to fabricate scaffolds by drop-on-demand printing. Bicine extended polyurethanes may be of interest for possible drug delivery applications, customizable scaffold fabrication and other potential biomedical applications. (C) 2008 Elsevier B.V. All rights reserved.