Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1
Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1
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DOI：
10.1016/j.ijbiomac.2015.08.016
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发表时间：
2015-11-01
影响因子：
8.2
通讯作者：
Qiu, Wanshou
中科院分区：
文献类型：
--
作者：
Liu, Ruilei;Li, Jie;Qiu, Wanshou
MicroRNAs exert their functions by mainly regulating coding genes or long non-coding RNA expression. In the present study, we reported that hsa-miR-1 was down-regulated in breast cancer tissues. Restoration of miR-1 in breast cancer cells inhibited proliferation, motility and increased apoptosis in vitro. miR-1 functioned as a tumor suppressor by targeting K-RAS and MALAT1. In addition, the effects of up-regulation of miR-1 were similar to that of silencing K-RAS and MALAT1 in breast cancer cells. In vivo study indicated that restoration of miR-1 inhibited tumor growth and metastasis. Patients with low miR-1 expression had poorer overall survival time than those with high miR-1 expression. Our findings emphasized the potential role of miR-1 as tumor suppressive miRNA in breast cancer. (C) 2015 Elsevier B.V. All rights reserved.
