Prostate shapes on pre-treatment MRI between prostate cancer patients who do and do not undergo biochemical recurrence are different: Preliminary Findings
Prostate shapes on pre-treatment MRI between prostate cancer patients who do and do not undergo biochemical recurrence are different: Preliminary Findings
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DOI：
10.1038/s41598-017-13443-8
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发表时间：
2017-11-20
影响因子：
4.6
通讯作者：
Madabhushi, Anant
中科院分区：
文献类型：
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作者：
Ghose, Soumya;Shiradkar, Rakesh;Madabhushi, Anant
早期识别治疗后有生化复发（BCR）风险的PCa患者，将可能通过新疗法或辅助疗法补充确定性治疗，以改善预后。确定性治疗后的BCR通常与可能导致前列腺肿胀的疾病进展相关。在这项工作中，我们探讨了基于图谱的比较方法是否揭示了在治疗前T2加权MRI上观察到的前列腺癌患者（BCR+）和不（BCR-）在确定性治疗后BCR之间的前列腺包膜形状差异。一项单中心IRB批准的研究纳入了874例患者。完整的图像数据集、临床定位的PCa、Gleason评分的可用性、治疗后PSA的可用数据和无BCR患者至少3年的随访是从874例患者中选择77例患者的入选标准。进一步控制Gleason评分、分期、年龄，并保持BCR+和BCR-类别的病例数量相等，将病例总数减少至50例。将手动分割的前列腺包膜与BCR-模板对齐，用于BCR+和BCR-组之间的统计学比较。在前列腺的外侧和后侧观察到两组之间具有统计学显著性的形状差异。
Early identification of PCa patients at risk for biochemical recurrence (BCR) post-therapy will potentially complement definitive therapy with either neo-or adjuvant therapy to improve prognosis. BCR post definitive therapy is often associated with disease progression that might cause a bulge in the prostate gland. In this work we explored if an atlas-based comparison approach reveals shape differences in the prostate capsule as observed on pre-treatment T2-weighted MRI between prostate cancer patients who do (BCR+) and do not (BCR-) have BCR following definitive therapy. A single center IRB approved study included 874 patients. Complete image datasets, clinically localized PCa, availability of Gleason score, data available for post-treatment PSA and follow-up for at least 3 years in patients without BCR were the inclusion criteria to select 77 patients out of the 874 patients. Further controlling for Gleason score, stage, age and to maintain equal number of cases for the BCR+ and BCR- categories, the total number of cases was reduced to 50. Manually segmented prostate capsules were aligned to a BCR- template for statistical comparison between the BCR+ and BCR- groups. Statistically significant shape difference between the two groups was observed towards the lateral and the posterior sides of prostate.