Unsaturated fatty acid feeding prevents the development of acute hepatitis in Long-Evans cinnamon (LEC) rats.
Unsaturated fatty acid feeding prevents the development of acute hepatitis in Long-Evans cinnamon (LEC) rats.
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不饱和脂肪酸喂养可预防长埃文斯肉桂 (LEC) 大鼠发生急性肝炎。
作者：
T. Shibata;H. Nagayasu;T. Kawano;H. Kitajo;J. Hamada;T. Moriuchi;F. Okada;S. Watanabe;S. Yasuda;H. Okuyama;H. Kobayashi;M. Arisue
为了研究膳食α-亚麻酸（18：3，n-3; alpha-LNA）和亚油酸（18：2，n-6; LA）对遗传性肝炎发展的影响，我们比较了饲喂补充红花油和补充紫苏油的饮食的Long-Evans肉桂（LEC）大鼠之间急性肝炎的发生率和等级。红花和紫苏油补充饮食减少肝炎的发病率和显着延长其发病时间相比，非补充的传统饮食。红花和紫苏油饲料对大鼠肝炎的发生率无显著性差异。在16周龄时，就在肝炎发作之前，与喂食α-亚麻酸盐和亚油酸盐的大鼠相比，喂食两种试验饮食的大鼠的血清转氨酶（AST，ALT）水平和铜浓度显著降低。由于防止血清铜升高，LEC大鼠中肝炎的发展具有抑制作用。
To investigate the effects of dietary alpha-linolenic acid (18:3, n-3; alpha-LNA) and linoleic acid (18:2, n-6; LA) on the development of hereditary hepatitis, we compared incidences and grades of acute hepatitis between the Long-Evans cinnamon (LEC) rats fed with safflower oil-supplemented diet and perilla oil-supplemented diet. Both safflower and perilla oil supplemented diets reduced the incidence of hepatitis and significantly prolonged its onset as compared to the non-supplemented conventional diet. No significant difference was observed between safflower and perilla oil diets in the rats of incidence of hepatitis. At the age of 16 weeks, just before the onset of hepatitis, serum levels of transaminase (AST, ALT) and concentration of copper in rats fed with both test diets were significantly reduced as compared with that of rats fed alpha-linolenate and linoleate have an inhibitory effect on the development of hepatitis in LEC rats due to the prevention of serum copper elevation.