Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder
Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder
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DOI：
10.1038/s41598-020-66784-2
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发表时间：
2020-06-16
影响因子：
4.6
通讯作者：
Ho, Roger C.
中科院分区：
文献类型：
--
作者：
Husain, Syeda Fabeha;Yu, Rongjun;Ho, Roger C.
使用功能性近红外光谱法（FNIRS）证明了主要抑郁症患者（MDD）额颞皮质（MDD）的血液动力学反应降低。最值得注意的是，在日本语音流利任务中，皮质氧 - 血红蛋白的变化可以将精神病患者与健康对照组（HC）区分开。但是，这种范式尚未用英语验证。因此，目前的工作旨在使用在英语字母流利任务中测量的血液动力学反应将MDD患者与HCS区分开。一百五个HC和105例MDD患者参加了这项研究。使用52通道系统获取了口头流利任务（VFT）期间的NIRS信号，并量化了额叶和颞区域中的氧 - 羟基珠蛋白的变化。注意到抑郁症的严重程度，社会心理功能，药物治疗和精神病史。与HCS相比，MDD患者在额叶和颞皮层中的氧氧蛋白变化较小。在这两个感兴趣的区域中，氧 - 羟蛋白蛋白与所研究的任何临床变量无关。 MDD患者中有75.2％和76.5％分别使用额叶和颞区氧 - 羟红球蛋白正确分类。在英语字母Fluency任务中，通过FNIRS测量的血液动力学反应是MDD的有希望的生物标志物。
Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychiatric patients from healthy controls (HC). However, this paradigm has not been validated in the English language. Therefore, the present work aimed to distinguish patients with MDD from HCs, using haemodynamic response measured during an English letter fluency task. One hundred and five HCs and 105 patients with MDD took part in this study. NIRS signals during the verbal fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were quantified. Depression severity, psychosocial functioning, pharmacotherapy and psychiatric history were noted. Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HCs. In both regions of interest, oxy-haemoglobin was not associated with any of the clinical variables studied. 75.2% and 76.5% of patients with MDD were correctly classified using frontal and temporal region oxy-haemoglobin, respectively. Haemodynamic response measured by fNIRS during an English letter fluency task is a promising biomarker for MDD.