Protecting-Group-Free Synthesis of Taiwaniaquinone H Using a One-Pot Thermal Ring Expansion/4 pi-Electrocyclization Strategy
Protecting-Group-Free Synthesis of Taiwaniaquinone H Using a One-Pot Thermal Ring Expansion/4 pi-Electrocyclization Strategy
复制标题
采用一锅热扩环/4 π 电环化策略无保护基合成台湾醌 H
DOI：
10.1021/jo5008652
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发表时间：
2014
影响因子：
3.6
通讯作者：
Hu Xiangdong
中科院分区：
文献类型：
--
作者：
Yan Xinxiang;Hu Xiangdong
以一锅热扩环/4π电环工艺为基础，建立了6-6-6三环支架策略。该方法的有效性已通过其在台湾亚喹酮H的全合成中的应用得到证明，该方法在无保护基团的情况下，分三步完成，总收率为14%。
A strategy to the 6-5-6 tricyclic scaffold of taiwaniaquinoids was established on the basis of a one-pot thermal ring expansion/4π-electrocyclization process. The efficiency of this methodology has been demonstrated through its application in the total synthesis of taiwaniaquinone H, which has been accomplished in three steps and 14% overall yield in a protecting-group-free manner starting from commercially available materials.