EPIDERMAL-GROWTH-FACTOR-DEPENDENT ACTIVATION OF THE SRC-FAMILY KINASES
EPIDERMAL-GROWTH-FACTOR-DEPENDENT ACTIVATION OF THE SRC-FAMILY KINASES
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DOI：
10.1111/j.1432-1033.1994.1047b.x
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发表时间：
1994-11-01
期刊：
影响因子：
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通讯作者：
LEVITZKI, A
中科院分区：
文献类型：
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作者：
OSHEROV, N;LEVITZKI, A
src型激酶作为信号转导子的确切作用一直在深入研究中，但只有在少数情况下，它们的作用才被详细揭示。因此，src、fyn和yes在血小板衍生生长因子或集落刺激因子的刺激下在高水平表达这些受体的细胞中被激活。src家族激酶被其他受体酪氨酸激酶如表皮生长因子（EGF）受体激活尚未得到直接证实。在这份报告中，我们证明表皮生长因子依赖性激活src家族酪氨酸激酶在NIH3T3细胞过表达的人表皮生长因子受体。快速激活（
The precise role of src-type kinases as signal transducers has been under intensive investigation but only in a few instances has their role been revealed in any detail. Thus, src, fyn and yes are activated upon stimulation by platelet-derived growth factor or colony-stimulating factor in cells expressing high levels of these receptors. Activation of src-family kinases by other receptor tyrosine kinases such as the epidermal-growth-factor (EGF) receptor has not been directly demonstrated. In this report, we demonstrate EGF-dependent activation of src-family tyrosine kinases in NIH3T3 cells overexpresssing the human EGF receptor. Activation is rapid (