The recency ratio is related to CSF amyloid beta 1-42 levels in MCI-AD
The recency ratio is related to CSF amyloid beta 1-42 levels in MCI-AD
复制标题
DOI：
10.1002/gps.5029
复制
发表时间：
2019-03-01
影响因子：
4
通讯作者：
Johnson, Sterling C.
中科院分区：
文献类型：
--
作者：
Bruno, Davide;Gleason, Carey E.;Johnson, Sterling C.
目的
随着抗淀粉样蛋白治疗干预从招募阿尔茨海默病（AD）痴呆患者转向临床前疾病患者，对能够无创、快速、可推广且具有成本效益地识别临床前状态的敏感措施的需求变得愈发重要。近因比率（Rr）是一种基于系列位置表现分析的记忆测量方法，已被发现可预测认知衰退以及向早期轻度认知障碍（MCI）的转变。本研究的目的是测试Rr对轻度认知障碍 - 阿尔茨海默病（MCI - AD）患者和对照组核心阿尔茨海默病生物标志物的脑脊液（CSF）水平的敏感性。
方法
对来自威斯康星阿尔茨海默病研究中心的126名参与者（110名对照组和16名MCI - AD患者）的基线数据进行了分析。在淀粉样蛋白β（Aβ40、Aβ42以及40/42比率）和tau（总tau和磷酸化tau）的脑脊液测量值与源自雷伊听觉词语学习测验的记忆测量值（Rr、延迟回忆和总回忆）之间，进行了针对人口统计学因素调整的偏相关分析。
结果
结果表明，在MCI - AD患者中，Rr是对Aβ42水平最敏感的记忆分数，而在对照组中，没有任何记忆分数与任何生物标志物显著相关。
结论
本研究表明，Rr是MCI - AD中潜在淀粉样蛋白β病理的敏感认知指标。
Objective As anti-amyloid therapeutic interventions shift from enrolling patients with Alzheimer's disease (AD) dementia to individuals with pre-clinical disease, the need for sensitive measures that allow for non-invasive, fast, disseminable, and cost-effective identification of preclinical status increases in importance. The recency ratio (Rr) is a memory measure that relies on analysis of serial position performance, which has been found to predict cognitive decline and conversion to early mild cognitive impairment (MCI). The aim of this study was to test Rr's sensitivity to cerebrospinal fluid (CSF) levels of the core AD biomarkers in individuals with MCI-AD and controls. Methods Baseline data from 126 (110 controls and 16 MCI-AD) participants from the Wisconsin Alzheimer's Disease Research Center were analysed. Partial correlations adjusting for demographics were carried out between CSF measure of amyloid beta (A beta 40, A beta 42, and the 40/42 ratio) and tau (total and phosphorylated), and memory measures (Rr, delayed recall, and total recall) derived from the Rey's Auditory Verbal Learning Test. ResultsResults indicated that Rr was the most sensitive memory score to A beta 42 levels in MCI-AD, while no memory score correlated significantly with any biomarker in controls. Conclusions This study shows that Rr is a sensitive cognitive index of underlying amyloid beta pathology in MCI-AD.