Iodine Status in Pregnant Women in the National Children's Study and in US Women (15-44 Years), National Health and Nutrition Examination Survey 2005-2010
Iodine Status in Pregnant Women in the National Children's Study and in US Women (15-44 Years), National Health and Nutrition Examination Survey 2005-2010
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DOI：
10.1089/thy.2013.0012
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发表时间：
2013-08-01
期刊：
影响因子：
6.6
通讯作者：
Moye, John
中科院分区：
文献类型：
--
作者：
Caldwell, Kathleen L.;Pan, Yi;Moye, John
背景：本报告介绍了来自国家健康和营养检查调查（NHANES）和国家儿童研究（NCS）先锋研究中孕妇样本的碘数据。方法：在NHANES 2005-2006年和2009-2010年参与者和所有2007-2008年6岁及以上参与者的三分之一亚样本中测量尿碘（UI）。这些测量值代表了一般的美国人口。UI也在全美7个研究地点的501名孕妇的便利样本中进行了测量，这些孕妇参加了NCS最初的先锋研究。结果：2009-2010年NHANES中位UI浓度（144 μ g/L）显著低于2007-2008年（164 μ g/L）。与非西班牙裔白人或西班牙裔相比，非西班牙裔黑人的UI浓度最低（131 μ g/L）（分别为147和148 μ g/L）。在NHANES 2005-2010中，所有孕妇的尿潴留浓度中位数低于正常值（129 μ g/L），而妊娠晚期妇女的尿潴留浓度中位数为正常值（172 μ g/L）。参加NCS的孕晚期妇女同样有足够的碘摄入量，平均尿浓度为167 μ g/L。此外，NCS中位UI浓度因地理位置而异。结论：乳制品与育龄妇女尿失禁中位浓度显著正相关，但与盐、海鲜或谷物消费无关。在2005-2010年的NHANES中，妊娠晚期的孕妇尿失尿中位数浓度足够，但在NHANES中，妊娠早期或中期的孕妇尿失尿中位数浓度不足。来自NHANES 2005-20010和NCS的非西班牙裔黑人孕妇的UI中位数浓度始终低于非西班牙裔白人或西班牙裔。
Background: This report presents iodine data from National Health and Nutrition Examination Survey (NHANES) and from a sample of pregnant women in the National Children's Study (NCS) Vanguard Study.Methods: Urinary iodine (UI) was measured in a one third subsample of NHANES 2005-2006 and 2009-2010 participants and in all 2007-2008 participants age 6 years and older. These measurements are representative of the general U.S. population. UI was also measured in a convenience sample of 501 pregnant women enrolled in the NCS initial Vanguard Study from seven study sites across the United States.Results: NHANES median UI concentration in 2009-2010 (144 mu g/L) was significantly lower than in 2007-2008 (164 mu g/L). Non-Hispanic blacks had the lowest UI concentrations (131 mu g/L) compared with non-Hispanic whites or Hispanics (147 and 148 mu g/L, respectively). The median for all pregnant women in NHANES 2005-2010 was less than adequate (129 mu g/L), while third trimester women had UI concentrations that were adequate (median UI 172 mu g/L). Third trimester women participating in the NCS similarly had an adequate level of iodine intake, with a median UI concentration of 167 mu g/L. Furthermore, NCS median UI concentrations varied by geographic location.Conclusions: Dairy, but not salt, seafood, or grain consumption, was significantly positively associated with median UI concentration in women of childbearing age. Pregnant women in their third trimester in the NHANES 2005-2010 had adequate median UI concentrations, but pregnant women in NHANES who were in their first or second trimesters had median UI concentrations that were less than adequate. Non-Hispanic black pregnant women from both the NHANES 2005-20010 and the NCS consistently had lower UI median concentrations than non-Hispanic whites or Hispanics.