The comparative effects of equimolar sevoflurane and isoflurane in isolated hearts.
The comparative effects of equimolar sevoflurane and isoflurane in isolated hearts.
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等摩尔七氟醚和异氟醚在离体心脏中的比较效果。
DOI：
10.1097/00000539-199511000-00023
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发表时间：
1995
影响因子：
5.7
通讯作者：
Stowe,DF
中科院分区：
文献类型：
--
作者：
Graf,BM;Vicenzi,MN;Bosnjak,ZJ;Stowe,DF
本研究的目的是比较等摩尔浓度的七氟烷（SEVO）和异氟烷（ISO）对离体心脏电生理学、机械功能、代谢和灌注的直接影响，不受神经元、体液或血流动力学影响。在Langendorff技术灌注的14只豚鼠心脏中随机给予三种等摩尔浓度的SEVO或ISO。直接测量自发心率（HR）、房室（AV）传导时间、左心室压（LVP）和冠状动脉流量（CF）。为了区分直接的血管扩张效应和由于CF自动调节引起的间接代谢效应，连续测量动脉和冠状窦氧分压，以计算氧输送（DO 2）、心肌耗氧量（MVO 2）、O（2）提取百分比和心脏效率。使用线性斜率分析（心脏效应作为0.1 mM麻醉剂浓度的函数）比较麻醉效应。只有AV时间增加更多（P< 0.05）由ISO（+1.8 ms/0.1 mM）比SEVO（+1.1 ms/0.1 mM）。ISO（+0.7 mL中心点g-1中心点min-1/0.1 mM）的CF往往高于SEVO（0.4 mL中心点g-1中心点min-1/0.1 mM），但这并不显著。HR（ISO，-1.4%/0.1 mM; SEVO，-1.7%/0.1 mM），LVP（ISO，-5.8%/0.1 mM; SEVO，-5.1%/0.1 mM）和O2提取百分比（ISO，每0.1 mM-6.1%; SEVO，-5.8%/0.1 mM）的降低相似，并且这些作用伴随着MVO 2的成比例降低（ISO，-34%+/-4%，SEVO，-37%+/-6%）。两种麻醉剂均未改变心脏效率。在离体心脏中，SEVO和ISO以浓度依赖性方式产生等效的负性变力、变时、代谢和血管舒张作用。只有AV传导延迟ISO比SEVO更多。
The aim of this study was to compare the direct effects of equivalent molar concentrations of sevoflurane (SEVO) and isoflurane (ISO) on electrophysiology, mechanical function, metabolism, and perfusion in isolated hearts, independent of neuronal, humoral, or hemodynamic influences. Three equimolar concentrations of SEVO or ISO were administered randomly in each of 14 guinea pig hearts perfused by the Langendorff technique. Spontaneous heart rate (HR), atrioventricular (AV) conduction time, left ventricular pressure (LVP), and coronary flow (CF) were measured directly. To differentiate a direct vasodilatory effect from an indirect metabolic effect due to autoregulation of CF, arterial and coronary sinus oxygen tension were measured continuously to calculate oxygen delivery (DO 2), myocardial oxygen consumption (MVO 2), percent O (2) extraction, and cardiac efficiency. Linear slope analysis (cardiac effect as a function of 0.1 mM anesthetic concentration) was used to compare anesthetic effects. Only AV time was increased more (P< 0.05) by ISO (+ 1.8 ms per 0.1 mM) than by SEVO (+ 1.1 ms per 0.1 mM). CF tended to be higher with ISO (+ 0.7 mL centered dot g-1 centered dot min-1 per 0.1 mM) than SEVO (0.4 mL centered dot g-1 centered dot min-1 per 0.1 mM) but this was not significant. HR (ISO,-1.4% per 0.1 mM; SEVO,-1.7% per 0.1 mM), LVP (ISO,-5.8% per 0.1 mM; SEVO,-5.1% per 0.1 mM), and percent O 2 extraction (ISO,-6.1% per 0.1 mM; SEVO,-5.8% per 0.1 mM) were decreased similarly by both anesthetics and these effects were accompanied by proportional decreases in MVO 2 (ISO,-34%+/-4%, SEVO,-37%+/-6%) at the highest concentrations (0.53 mM). Neither anesthetic altered cardiac efficiency. SEVO and ISO produce equivalent negative inotropic, chronotropic, metabolic, and vasodilatory effects in a concentration-dependent manner in isolated hearts. Only AV conduction is delayed more by ISO than by SEVO.