Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease
Leptin: Linking obesity, the metabolic syndrome, and cardiovascular disease
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DOI：
10.1007/s11906-008-0025-y
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发表时间：
2008-04-01
影响因子：
5.6
通讯作者：
Villarreal, Daniel
中科院分区：
文献类型：
--
作者：
Patel, Sanjeev B.;Reams, Garry P.;Villarreal, Daniel
肥胖和代谢综合征的发病率和患病率在过去十年中显著上升，是严重的心血管健康危害，具有显著的发病率和死亡率。代谢综合征的病因及其各种致病机制尚未完全确定，正在进行深入研究。当代研究表明，脂肪细胞源性激素瘦素可能是一个重要的因素联系肥胖，代谢综合征，心血管疾病。虽然最近的证据表明，在正常情况下，瘦素可能是一个重要的因素，在调节压力和容量，在慢性高瘦素血症和瘦素抵抗的情况下，这种激素可能会在病理生理上的高血压和心脏和肾脏疾病的发展。未来的研究将确定是否减少循环中的瘦素和/或阻断其外周作用可以赋予肥胖和代谢综合征的高瘦素血症患者心血管和肾脏保护。
The incidence and prevalence of obesity and the metabolic syndrome have risen markedly in the past decade, representing a serious cardiovascular health hazard with significant morbidity and mortality. The etiology of the metabolic syndrome and its various pathogenic mechanisms are incompletely defined and under intense investigation. Contemporary research suggests that the adipocyte-derived hormone leptin may be an important factor linking obesity, the metabolic syndrome, and cardiovascular disorders. Although recent evidence indicates that under normal conditions leptin may be an important factor in regulating pressure and volume, during situations of chronic hyperleptinemia and leptin resistance, this hormone may function pathophysiologically for the development of hypertension and cardiac and renal diseases. Future research will determine if reduction of circulating leptin and/or blockade of its peripheral actions can confer cardiovascular and renal protection in hyperleptinemic patients with obesity and the metabolic syndrome.