Predicted vitamin D status and incidence of tooth loss and periodontitis.
Predicted vitamin D status and incidence of tooth loss and periodontitis.
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DOI：
10.1017/s1368980013000177
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发表时间：
2014-04
影响因子：
3.2
通讯作者：
Dietrich T
中科院分区：
文献类型：
--
作者：
Jimenez M;Giovannucci E;Krall Kaye E;Joshipura KJ;Dietrich T
维生素D不足非常普遍，特定亚群的风险更大（例如老年人和皮肤较黑的人）。维生素D不足可能部分解释美国种族/民族牙周炎和牙齿脱落的患病率差异。我们评估了血浆25-羟基维生素D（25（OH）D）预测评分与牙周炎和牙齿脱落发病率之间的关系。每两年收集一次关于病史、生活方式、牙周炎和牙齿脱落的详细问卷。预测因子评分来源于已知影响血浆25（OH）D循环浓度的变量，并根据子样本中的血浆浓度进行验证。多变量考克斯比例风险模型与随时间变化的协变量估计预测的25（OH）D评分和时间之间的关联，直到第一个牙齿脱落。从1986年到2006年，共有42730名基线年龄在40-75岁之间的卫生专业人员随访研究参与者接受了随访。美国，代表所有50个州和哥伦比亚特区。我们观察了539335人年的13581例牙齿脱落事件。在预测的25（OH）D评分和牙齿脱落发生率的五分位数之间存在剂量依赖性显著负相关。在多变量分析中，更新的25（OH）D预测评分的最高五分位数与最低五分位数相比，与牙齿脱落发生率降低20%相关（风险比5.080，95%CI 0.76，0.85;趋势P值<0.001）; UV-B也独立相关。预测的25（OH）D评分和牙周炎的结果相似。这些结果提示维生素D的预测因子与牙齿脱落和牙周炎的发病率较低之间存在关联。
Vitamin D insufficiency is highly prevalent, with particular subgroups at greater risk (e.g. the elderly and those with darker skin). Vitamin D insufficiency may partly explain US racial/ethnic disparities in the prevalence of periodontitis and tooth loss. We evaluated the association between a predictor score of plasma 25-hydroxyvitamin D (25(OH)D) and incidence of periodontitis and tooth loss. Detailed biennial questionnaires were collected on medical history, lifestyle practices and incident periodontitis and tooth loss. The predictor score was derived from variables known to influence circulating concentrations of plasma 25(OH)D and validated against plasma concentrations among a sub-sample. Multivariable Cox proportional-hazards models with time-varying covariates estimated the association between the predicted 25(OH)D score and time until first tooth loss. A total of 42 730 participants of the Health Professionals Follow-Up Study aged 40–75 years at baseline were followed from 1986 to 2006. USA, representing all fifty states and the District of Columbia. We observed 13 581 incident tooth loss events from 539 335 person-years. There was a dose-dependent significant inverse association across quintiles of the predicted 25(OH)D score and incidence of tooth loss. In multivariable analyses, the highest quintile of the updated predicted 25(OH)D score compared with the lowest was associated with a 20 % lower incidence of tooth loss (hazard ratio 5 0·80, 95 % CI 0·76, 0·85; P value for trend <0·0 0 1); UV-B was also independently associated. Results for the predicted 25(OH)D score and periodontitis were similar. These results are suggestive of an association between predictors of vitamin D and lower incidence of tooth loss and periodontitis.