T cell clones to two major T cell epitopes of myoglobin: effect of I-A/I-E restriction on epitope dominance.
T cell clones to two major T cell epitopes of myoglobin: effect of I-A/I-E restriction on epitope dominance.
复制标题
T 细胞克隆至肌红蛋白的两个主要 T 细胞表位：I-A/I-E 限制对表位优势的影响。
作者：
I. Berkower;H. Kawamura;L. Matis;J. Berzofsky
The murine T cell response to sperm whale myoglobin was analyzed for polyclonal and monoclonal T cells. For polyclonal T cells, the immunodominant epitope included residue Glu 109 when the antigen-presenting cells expressed I-Ad, whereas a Lys 140-containing epitope was immunodominant when the antigen-presenting cells expressed I-Ed only. Monoclonal T cells specific for each epitope were derived from a polyclonal line. T cell clones specific for the Glu 109 epitope were restricted to I-Ad, whereas the clones specific for the Lys 140 epitope were restricted to I-Ed. Thus, for an antigen that can be presented in association with either I-Ad or I-Ed, the immunodominance of particular epitopes depends strongly on the restriction element used. The immunodominance of each epitope-Ia combination may be due to a limited repertoire of T cells or selective presentation of epitope and Ia by accessory cells.
