REGIONAL LUNG DENSITY AND BLOOD-VOLUME IN NONSMOKING AND SMOKING SUBJECTS MEASURED BY PET
REGIONAL LUNG DENSITY AND BLOOD-VOLUME IN NONSMOKING AND SMOKING SUBJECTS MEASURED BY PET
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DOI：
10.1152/jappl.1987.63.4.1324
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发表时间：
1987-10-01
影响因子：
3.3
通讯作者：
HUGHES, JMB
中科院分区：
文献类型：
--
作者：
BRUDIN, LH;RHODES, CG;HUGHES, JMB
采用正电子发射断层扫描（PET）和11 CO（吸入）标记红细胞，对30名健康仰卧受试者（15名吸烟者和15名非吸烟者）在1.7 cm厚的胸中段横截面上进行潮气呼吸时的局部肺密度（DL）和局部肺血容量分数（VB）进行定量测量。计算局部肺泡容积（VA）、血管外肺密度（DEV）和相对肺泡大小（Valv = VA/DEV）。对于非吸烟者，平均值（±）。右肺的受试者之间的SD）如下：DL，0.28 ±。0.03 g/cm ~ 3; VA，0.73 ±。0.03 ml/cm ~ 3; VB0.16 ±. 0.02 ml/cm ~ 3; DEV为0.10 ±. 0.02 g/cm 3;和Valv，7.1 . ±. 1.9 ml/g肺组织。在吸烟者中，DEV（右肺加左肺）高出16%。吸烟者与不吸烟者之间的VB无显著性差异，左右肺之间的DEV和VB无显著性差异。平均值（±）非吸烟者右肺背腹比的计算值为：DL，1.34 ±。0.16; VA，0.90 ±。0.05; VB，1.52 ±。0.26; DEV，1.10 . ±. 0.17;和Valv，0.85 . ±. 0.19.在吸烟者中发现了几乎相同的比例。在一名受试者中研究了在自主过度充气和呼气末正压期间整体胸廓扩张的影响。
Regional lung density (DL) and regional fractional pulmonary blood volume (VB) were measured quantitatively during tidal breathing in 30 healthy supine subjects (15 smokers and 15 nonsmokers) in a 1.7-cm-thick midthoracic cross section using positron emission tomography (PET) and 11CO (inhaled)-labeled erythrocytes. Regional alveolar volume (VA), extravascular lung density (DEV), and relative alveolar size (Valv = VA/DEV) were calculated. For the nonsmokers, mean values (.+-. SD) between subjects) for the right lung were as follows: DL, 0.28 .+-. 0.03 g/cm3 thorax; VA, 0.73 .+-. 0.03 ml/cm3; VB 0.16 .+-. 0.02 ml/cm3; DEV, 0.10 .+-. 0.02 g/cm3; and Valv, 7.1 .+-. 1.9 ml/g lung tissue. In the smoking subjects DEV (right plus left lung) was 16% higher. No significant difference in VB between smokers and nonsmokers was found. The differences in DEV and VB between right and left lung were not significant. Mean values (.+-.SD) of the dorsal-to-ventral ratios calculated for the right lung in the nonsmokers were as follows: DL, 1.34 .+-. 0.16; VA, 0.90 .+-. 0.05; VB, 1.52 .+-. 0.26; DEV, 1.10 .+-. 0.17; and Valv, 0.85 .+-. 0.19. Almost identical ratios were found in the smokers. The influence of overall thoracic expansion was investigated in one subject restudied during voluntary hyperinflation and during positive end-expiratory pressure.