Regulation of antral gastrin content.
Regulation of antral gastrin content.
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胃窦胃泌素含量的调节。
DOI：
10.1152/ajpgi.1983.245.6.g725
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Guthrie,PD
中科院分区：
文献类型：
--
作者：
Johnson,LR;Guthrie,PD
5组大鼠禁食3天，每8小时注射NaCl或5、10、20或40 μ g/kg蛙皮素。将动物处死，并将其血清和胃窦胃泌素水平与正常喂养的大鼠进行比较。禁食使血清胃泌素降至对照组的14%;胃窦胃泌素降至对照组的21%。所有剂量的蛙皮素显著增加禁食大鼠的血清胃泌素，20和40微克/公斤显著增加胃窦胃泌素。一组正常喂养的大鼠也进行了比较，一个喂养了7天的液体饮食。其中一半注射20微克/千克蛙皮素（3次/天），另一半注射NaCl。蛙皮素能显著提高固体食物喂养大鼠的血清和胃窦胃泌素水平。流质饮食降低血清和胃窦胃泌素的17和59%的控制值，分别。蛙皮素注射完全阻止了这些下降。这些数据表明胃肠道中的食物对于胃泌素的释放或合成是不需要的。此外，数据表明，胃泌素的合成主要是由胃泌素释放或直接刺激蛙皮素，而不是由特定的食品调节。
Five groups of rats were fasted for 3 days and injected with either NaCl or 5, 10, 20, or 40 micrograms/kg bombesin every 8 h. The animals were killed, and their serum and antral gastrin levels were compared with those of normally fed rats. Fasting reduced serum gastrin to 14% of control; antral gastrin was reduced to 21% of control. All doses of bombesin significantly increased serum gastrin in fasted rats, and 20 and 40 micrograms/kg significantly increased antral gastrin. A group of normally fed rats was also compared with one fed a liquid diet for 7 days. Half of each of these was injected with 20 micrograms/kg bombesin (3 times/day) and the other half with NaCl. Bombesin significantly increased serum and antral gastrin in the rats fed solid food. The liquid diet lowered serum and antral gastrin to 17 and 59% of control values, respectively. Bombesin injection totally prevented these decreases. These data indicate that food in the gastrointestinal tract is not required for either gastrin release or synthesis. Furthermore, the data suggest that gastrin synthesis is regulated primarily by gastrin release or by direct stimulation by bombesin rather than by specific food products.