Mechanical properties of porcine and human arteries: Implications for coronary anastomotic connectors
Mechanical properties of porcine and human arteries: Implications for coronary anastomotic connectors
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DOI：
10.1016/s0003-4975(03)00263-7
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发表时间：
2003-07-01
影响因子：
4.6
通讯作者：
Borst, C
中科院分区：
文献类型：
--
作者：
van Andel, CJ;Pistecky, PV;Borst, C
背景。为了确定猪是否是研究冠状动脉搭桥手术中远端吻合连接器的合适实验动物，在品系生理范围内和之外比较了年轻猪和老年猪冠状动脉和乳内动脉的机械特性。方法。研究了 6 人和 8 头猪的冠状动脉以及 3 人和 6 头猪（人，年龄 61 至 85 岁；猪，78.7 +/- 5.8 kg [平均值 +/- SD]）的内乳动脉。测量压力-直径、压力-轴向力、周向和轴向应力-应变关系以及尺寸。结果。猪和人的冠状动脉和乳内动脉的尺寸大体相似，但猪内乳动脉的壁厚较小（分别为 0.35 +/- 0.07 毫米与 0.71 +/- 0.06 毫米，p = 0.002）。猪内乳动脉壁的弹性低于冠状动脉壁，而人类的两条动脉显示出相似的弹性。总体而言，与人动脉相比，猪动脉在圆周方向和轴向方向上都更具弹性。因此，在达到最大周向应变之前，猪动脉可以安全地拉伸 60% 至 70%，而人类动脉则为 20% 左右。结论。与人类冠状动脉和乳内动脉壁相比，猪的弹性大三倍，当在猪中评估涉及壁过度拉伸的冠状连接器时，可能会导致壁应力和壁损伤风险的低估。 (C) 2003 年，胸外科医师协会。
Background. To determine whether the pig is an appropriate experimental animal for studies on distal anastomotic connectors in coronary artery bypass surgery, the mechanical properties of young porcine and old human coronary and internal mammary arteries were compared within and beyond the physiologic range of strains.Methods. Coronary arteries from 6 humans and 8 pigs were studied as well as internal mammary arteries of 3 humans and 6 pigs (human, aged 61 to 85 years; pig, 78.7 +/- 5.8 kg [mean +/- SD]). Pressure-diameter, pressure-axial force, circumferential and axial stress-strain relations, and dimensions were measured.Results. The dimensions of the porcine and human coronary and internal mammary artery were generally similar but wall thickness was smaller in the porcine internal mammary artery (0.35 +/- 0.07 mm versus 0.71 +/- 0.06 mm, respectively, p = 0.002). The porcine internal mammary artery wall was less elastic than the coronary artery wall, whereas in humans both arteries displayed similar elasticity. Overall the porcine arteries were far more elastic in both circumferential and axial direction compared with the human arteries. Consequently the porcine arteries could be safely stretched by 60% to 70% compared with about 20% for the human arteries before reaching their maximum circumferential strain.Conclusions. The three times greater elasticity of porcine compared with human coronary and internal mammary artery walls may result in underestimation of wall stress and the risk of wall injury when coronary connectors that involve overstretching of the wall are evaluated in the pig. (C) 2003 by The Society of Thoracic Surgeons.