Human placental receptors for luteinizing hormone releasing hormone.
Human placental receptors for luteinizing hormone releasing hormone.
复制标题
人类胎盘黄体生成素释放激素受体。
DOI：
10.1016/0006-291x(81)91749-6
复制
发表时间：
1981
影响因子：
3.1
通讯作者：
R. Sharpe
中科院分区：
文献类型：
--
作者：
A. Currie;H. Fraser;R. Sharpe
人足月胎盘质膜制备物结合125 I标记的促黄体生成素释放激素（LHRH）激动剂，具有高亲和力（KA= 5.5× 107 M −1）和特异性。天然LHRH以相同的亲和力（KA= 6.2 × 107 M −1）竞争结合，而LHRH激动剂、催产素、生长抑素和TRH的片段没有或只有最小的置换。妊娠10周的胎盘和单个葡萄胎的膜制品也含有LHRH受体，其特征与足月胎盘相似。据我们所知，这是第一次证明垂体外LHRH受体在人类。
Plasma membrane preparations of human term placenta bound125I-labelled luteinizing hormone releasing hormone (LHRH) agonist with high affinity (KA= 5.5×107M−1) and specificity. Native LHRH competed for binding with the same affinity (KA= 6.2 × 107M−1) whereas fragments of the LHRH agonists, oxytocin, somatostatin and TRH gave no or minimal displacement. Placenta from 10 week's gestation and membrane preparations from a single hydatidiform mole also contained LHRH receptors with similar characteristics to those found in term placenta. To our knowledge this is the first demonstration of extra-pituitary LHRH receptors in the human.