Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins
Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins
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DOI：
10.1016/j.jconrel.2010.07.111
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发表时间：
2010-11-20
影响因子：
10.8
通讯作者：
Grijpma, Dirk W.
中科院分区：
文献类型：
--
作者：
Seck, Tetsu M.;Melchels, Ferry P. W.;Grijpma, Dirk W.
设计的三维可生物降解的聚（乙二醇）/聚（D，L-丙交酯）水凝胶结构的制备首次通过立体光刻在高分辨率。使用在DMSO/水中包含基于PDLLA-PEG-PDLLA的大分子单体、可见光光引发剂、染料和抑制剂的可光聚合水性树脂来构建结构。制备了具有明确结构和良好力学性能的多孔和无孔水凝胶。具有螺旋状孔网络结构的多孔水凝胶结构显示出窄的孔径分布、优异的孔互连性和良好的机械性能。该结构具有良好的细胞接种特性，人骨髓间充质干细胞在这些材料上粘附和增殖良好。(C)2010 Elsevier B. V.保留所有权利。
Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials. (C) 2010 Elsevier B.V. All rights reserved.